LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

[1] Siegel RL(2018)Cancer statistics, 2018 CA Cancer J Clin 68 7-30

[2] Miller KD(2018)Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries Lancet 391 1023-1075

[3] Jemal A(2011)Hallmarks of cancer: the next generation Cell 144 646-674

[4] Allemani C(2017)Metabolic profiling of gemcitabine- and paclitaxel-treated immortalized human pancreatic cell lines with K-RAS(G12D) Biomed Res 38 29-40

[5] Matsuda T(2017)Drug resistance in pancreatic cancer: impact of altered energy metabolism Crit Rev Oncol Hematol 114 139-152

[6] Di Carlo V(2016)Differential glutamate metabolism in proliferating and quiescent mammary epithelial cells Cell Metab 23 867-880

[7] Harewood R(2015)Metabolism. Differential regulation of mTORC1 by leucine and glutamine Science 347 194-198

[8] Matz M(2017)Glutaminolysis: a Hallmark of Cancer metabolism Annu Rev Biomed Eng 19 163-194

[9] Niksic M(2015)L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia Am J Cancer Res 5 1281-1294

[10] Hanahan D(1999)Identification and functional characterization of a Na+−independent neutral amino acid transporter with broad substrate selectivity J Biol Chem 274 19745-19751

[1] Siegel RL(2018)Cancer statistics, 2018 CA Cancer J Clin 68 7-30

[2] Miller KD(2018)Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries Lancet 391 1023-1075

[3] Jemal A(2011)Hallmarks of cancer: the next generation Cell 144 646-674

[4] Allemani C(2017)Metabolic profiling of gemcitabine- and paclitaxel-treated immortalized human pancreatic cell lines with K-RAS(G12D) Biomed Res 38 29-40

[5] Matsuda T(2017)Drug resistance in pancreatic cancer: impact of altered energy metabolism Crit Rev Oncol Hematol 114 139-152

[6] Di Carlo V(2016)Differential glutamate metabolism in proliferating and quiescent mammary epithelial cells Cell Metab 23 867-880

[7] Harewood R(2015)Metabolism. Differential regulation of mTORC1 by leucine and glutamine Science 347 194-198

[8] Matz M(2017)Glutaminolysis: a Hallmark of Cancer metabolism Annu Rev Biomed Eng 19 163-194

[9] Niksic M(2015)L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia Am J Cancer Res 5 1281-1294

[10] Hanahan D(1999)Identification and functional characterization of a Na+−independent neutral amino acid transporter with broad substrate selectivity J Biol Chem 274 19745-19751