TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells

被引：0
作者：
Ageliki Tsagaratou
Edahí González-Avalos
Sini Rautio
James P Scott-Browne
Susan Togher
William A Pastor
Ellen V Rothenberg
Lukas Chavez
Harri Lähdesmäki
Anjana Rao
机构：
[1] La Jolla Institute for Allergy and Immunology,Department of Signaling and Gene Expression
[2] Aalto University School of Science,Department of Computer Science
[3] Sanford Consortium for Regenerative Medicine,Division of Biology and Biological Engineering
[4] California Institute of Technology,Division of Pediatric Neurooncology
[5] German Cancer Research Center (DKFZ),Department of Pharmacology and Moores Cancer Center
[6] University of California at San Diego,undefined
[7] Present address: Department of Molecular,undefined
[8] Cell and Developmental Biology,undefined
[9] University of California at Los Angeles,undefined
[10] Los Angeles,undefined
[11] California,undefined
[12] USA.,undefined
来源：
Nature Immunology | 2017年 / 18卷
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D O I：
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学科分类号：
摘要：
TET proteins regulate 5-methylcytosine epigenetic marks, and thereby regulate chromatin accessibility. Rao and colleagues show that the combined loss of TET2 and TET3 in thymocytes skews development to iNKT17 cells as a result of upregulation of RORγt, which leads to lymphoproliferative disease and premature death.
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页码：45 / 53
页数：8
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