Influence of C-H...O interactions on the structural stability of β-lactamases

被引：0
作者：
P. Lavanya
Sudha Ramaiah
Anand Anbarasu
机构：
[1] VIT University,Medical & Biological Computing Laboratory, School of Biosciences and Technology
来源：
Journal of Biological Physics | 2013年 / 39卷
关键词：
β-lactamases; CH...O interactions; Stabilization centers; Conservation; Solvent accessibility; Secondary structure;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
β-Lactamases produced by pathogenic bacteria cleave β-lactam antibiotics and render them ineffective. Understanding the principles that govern the structural stability of β-lactamases requires elucidation of the nature of the interactions that are involved in stabilization. In the present study, we systematically analyze the influence of CH...O interactions on determining the specificity and stability of β-lactamases in relation to environmental preferences. It is interesting to note that all the residues located in the active site of β-lactamases are involved in CH...O interactions. A significant percentage of CH...O interactions have a higher conservation score and short-range interactions are the predominant type of interactions in β-lactamases. These results will be useful in understanding the stability patterns of β-lactamases.
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页码：649 / 663
页数：14
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