n-3 Polyunsaturated Fatty Acids and Their Role in Cancer Chemoprevention

被引：22
作者：
Gu Z. [1 ,2 ,3 ]
Shan K. [1 ,2 ]
Chen H. [1 ,2 ]
Chen Y.Q. [1 ,2 ,3 ]
机构：
[1] State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi
[2] The Synergistic Innovation Center for Food Safety and Nutrition, Wuxi
[3] Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, 27157, NC
来源：
Current Pharmacology Reports | 2015年 / 1卷 / 5期
基金：
中国国家自然科学基金; 美国国家卫生研究院;
关键词：
Cancer; Chemotherapy; Inflammation; Lipid mediator; n-3 Polyunsaturated fatty acids;
D O I：
10.1007/s40495-015-0043-9
中图分类号：
学科分类号：
摘要：
Polyunsaturated fatty acids (PUFAs), including omega-3 (n-3) and omega-6 (n-6) PUFAs, are essential for human health. Recent research shows n-3 PUFAs and their mediators can inhibit inflammation, angiogenesis, and cancer via multiple mechanisms, including reduced release of n-6 fatty acid arachidonic acid from cell membranes, inhibition of enzymatic activities, and direct competition with arachidonic acid for enzymatic conversions. In this review, we discuss inflammation-related cancer, anti-inflammatory effects of n-3 PUFA lipid mediators, and antineoplastic activities of n-3 PUFA in vitro and in vivo and present an update on recent human trials. © 2015, Springer International Publishing AG.
引用
收藏
页码：283 / 294
页数：11
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