Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

被引：0

作者：

Derek J. Richard

Emma Bolderson

Liza Cubeddu

Ross I. M. Wadsworth

Kienan Savage

Girdhar G. Sharma

Matthew L. Nicolette

Sergie Tsvetanov

Michael J. McIlwraith

Raj K. Pandita

Shunichi Takeda

Ronald T. Hay

Jean Gautier

Stephen C. West

Tanya T. Paull

Tej K. Pandita

Malcolm F. White

Kum Kum Khanna

机构：

[1] Signal Transduction Laboratory,Central Clinical Division

[2] Queensland Institute of Medical Research,Department of Radiation Oncology

[3] Brisbane,Department of Molecular Genetics and Microbiology

[4] Queensland 4029,Department of Radiation Genetics

[5] Australia,Division of Gene Regulation and Expression

[6] Centre for Biomolecular Sciences,undefined

[7] University of St Andrews,undefined

[8] North Haugh,undefined

[9] St Andrews,undefined

[10] Fife KY16 9ST,undefined

[11] UK,undefined

[12] School of Molecular and Microbial Biosciences,undefined

[13] University of Sydney,undefined

[14] Sydney,undefined

[15] New South Wales 2006,undefined

[16] Australia,undefined

[17] School of Medicine,undefined

[18] University of Queensland,undefined

[19] Washington University School of Medicine,undefined

[20] St Louis,undefined

[21] Missouri 63108,undefined

[22] USA,undefined

[23] University of Texas at Austin,undefined

[24] Austin,undefined

[25] Texas 78712,undefined

[26] USA,undefined

[27] London Research Institute,undefined

[28] Clare Hall Laboratories,undefined

[29] Cancer Research UK,undefined

[30] South Mimms,undefined

[31] Hertfordshire EN6 3LD,undefined

[32] U.K,undefined

[33] Kyoto University Graduate School of Medicine,undefined

[34] Wellcome Biocentre,undefined

[35] University of Dundee,undefined

[36] Institute for Cancer Genetics,undefined

[37] Columbia University Medical Center,undefined

[38] New York,undefined

[39] New York 10032,undefined

[40] USA,undefined

来源：

Nature | 2008年 / 453卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Single-stranded DNA (ssDNA) in a cell is highly prone to degradation, so cells shield ssDNA from nucleases by coating it with ssDNA-binding proteins (SSBs). In eukaryotes, the canonical SSB is a heterotrimer known as RPA. In this work, Khanna and colleagues characterize a second SSB from human cells, which they call hSSB1. Unlike RPA, hSSB1 is a single protein. Its primary function seems to be in the cellular response to DNA damage.

引用

页码：677 / 681

页数：4

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