1-Substituted 2-Benzylaminobenzimidazoles with Phenyl Methoxyls: Synthesis, Computer Prediction, and Pharmacological Activity

被引：0
作者：
O. N. Zhukovskaya
V. A. Anisimova
A. A. Spasov
P. M. Vasil’ev
V. A. Kosolapov
A. F. Kucheryavenko
N. A. Gurova
L. V. Naumenko
V. A. Kuznetsova
D. V. Sorotskii
O. A. Solov’eva
E. V. Reznikov
V. V. Gurova
V. S. Sirotenko
机构：
[1] Southern Federal University,Research Institute of Physical and Organic Chemistry
[2] Volgograd State Medical University,Research Institute of Pharmacology
[3] Volgograd State Medical University,Volgograd Medical Scientific Center
[4] Russian Academy of Medical Sciences,undefined
来源：
Pharmaceutical Chemistry Journal | 2016年 / 49卷
关键词：
1-substituted 2-benzylaminobenzimidazoles; synthesis; Microcosm IT tool; search; antiarrhythmic, antiaggregant, antioxidant, hemorheologic, and antiglycating activity; experimental study;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Condensation of 1-substituted 2-aminobenzimidazoles with aromatic aldehydes produced the corresponding azomethines, reduction of which by sodium borohydride afforded 1-substituted 2-benzylaminobenzimidazoles. The Microcosm information technology (IT) tool was used to assess in silico the potential for antiarrhythmic, antiaggregant, antioxidant, hemorheologic, and antiglycating activity in this series of compounds. Pharmacological screening identified which of the synthesized compounds were active. It was shown that the computer predictions correlated with the experimental data.
引用
收藏
页码：735 / 742
页数：7
相关论文
共 20 条
[1]  
DeSimone RW(2004)undefined Comb. Chem. High Throughput Screening 7 473-493
[2]  
Currie KS(2007)undefined Ernst Schering Found. Symp. Proc. 2 75-91
[3]  
Mitchell SA(2012)undefined Bioorg. Med. Chem. 20 6208-6236
[4]  
Bywater RP(1992)undefined Eur. J. Med. Chem. 27 395-400
[5]  
Bansal Y(2006)undefined Ross. Khim. Zh. (Zh. Ross. Khim. O’va im. D. I. Mendeleeva) 50 108-127
[6]  
Silakari O(1968)undefined Farmakol. Toksikol. 31 41-44
[7]  
Da Settimo A(1989)undefined Lab. Delo 10 15-18
[8]  
Primofiore G(1996)undefined Eksp. Klin. Farmakol. 59 54-55
[9]  
Da Settimo F(2005)undefined Naresuan Univ. J. 13 35-41
[10]  
Vasil’ev PM(undefined)undefined undefined undefined undefined-undefined
12