Age-Related Changes in Proteoglycan Composition in Rat Brain

被引：0
作者：
E. Yu. Leberfarb
V. I. Rykova
N. G. Kolosova
G. M. Dymshits
机构：
[1] Siberian Division of the Russian Academy of Sciences,Institute of Cytology and Genetics
来源：
Bulletin of Experimental Biology and Medicine | 2008年 / 146卷
关键词：
proteoglycans; chondroitin sulfates; heparan sulfates; brain; aging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Brain proteoglycans play an important role in learning and memory processes and in the pathogenesis of neurodegenerative disease. Brain proteoglycans in Wistar rats and early aging OXYS rats at the age of 1, 2, and 14 months were compared. Proteoglycan content in OXYS rats aged 1 and 2 months is 2-fold lower than in Wistar. The content of proteoglycans 7-fold decreases in Wistar and OXYS rats with age at the expense of heparan sulfates and chondroitin sulfates and by the age of 14 months, the difference between the strains is leveled. These results indicate that cognitive and emotional disorders observed in OXYS rats by the age of 3 months develop against the background of significant changes in the content and composition of proteoglycans.
引用
收藏
页码：797 / 799
页数：2
相关论文
共 34 条
[1]  
Agafonova IG(2007)undefined Byull. Eksp. Biol. Med. 143 467-471
[2]  
Kolosova NG(2000)undefined Ibid. 130 155-158
[3]  
Mishchenko NP(2007)undefined Cur. Opin. Neurobiol. 17 120-127
[4]  
Loskutova LV(2005)undefined Ibid. 15 116-120
[5]  
Kolosova NG(2007)undefined Brain Res. 54 1-18
[6]  
Busch SA(2007)undefined Yakugaku Zasshi 127 563-570
[7]  
Silver J(2006)undefined Neurobiol. Aging 27 1289-1297
[8]  
Carulli D(2004)undefined Congenit. Anom. (Kyoto) 44 181-188
[9]  
Laabs T(1996)undefined J. Comp. Neurol. 366 44-54
[10]  
Geller HM(2006)undefined Exp. Gerontol. 41 141-150
1234