Pediatric Mixed Connective Tissue Disease

被引：0
作者：
Roberta A. Berard
Ronald M. Laxer
机构：
[1] Children’s Hospital,Section of Rheumatology
[2] London Health Sciences Centre,Department of Pediatrics
[3] Western University,Division of Rheumatology
[4] The Hospital for Sick Children,Department of Pediatrics and Medicine
[5] University of Toronto,undefined
来源：
Current Rheumatology Reports | 2016年 / 18卷
关键词：
Pediatric; Mixed connective tissue disease; Etiopathogenesis; Treatment; Outcome;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pediatric-onset mixed connective tissue disease is among the rare disease entities in pediatric rheumatology and includes features of arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, and systemic sclerosis. Accurate recognition and diagnosis of the disease is paramount to prevent long-term morbidity. Advances in the genetic and immunologic understanding of the factors involved in the etiopathogenesis provide an opportunity for improvements in prognostication and targeted therapy. The development of a multinational cohort of patients with mixed connective tissue disease would be invaluable to provide more updated data regarding the clinical presentation, to develop a standardized treatment approach, disease activity and outcome tools, and to provide data on long-term outcomes and comorbidities.
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