The effect of the atelocollagen matrix and bFGF on bone regeneration in defects of the calvaria of rats

被引：0

作者：

Nakamura M. ^{[1
]}

Kobayashi K. ^{[2
]}

Hirano A. ^{[3
]}

机构：

[1] Department of Plastic and Reconstructive Surgery, Nagasaki Yuai Hospital, Nagasaki 851-0401

[2] Department of Plastic and Reconstructive Surgery, Ehime Prefectural Hospital, Matsuyama

[3] Division of Plastic and Reconstructive Surgery, Nagasaki University Graduate School of Biomedical Science, Nagasaki

来源：

European Journal of Plastic Surgery | 2006年 / 28卷 / 8期

关键词：

Atelocollagen matrix; bFGF; Bone regeneration;

D O I：

10.1007/s00238-006-0038-1

中图分类号：

学科分类号：

摘要：

The purpose of this study was to evaluate the effect of the atelocollagen matrix and basic fibroblast growth factor (bFGF) on bone regeneration in a bone defect of the calvaria. The subjects were 10-week-old male Wister rats weighing 350 g. Two kinds of atelocollagen matrices, which were either strongly cross-linked or weakly cross-linked, were placed in defects created in the rat cranium. Two doses of bFGF, either 30 μg or 50 μg, were injected into the weakly cross-linked atelocollagen matrix. Both the bone mineral content in the defects and the area of bone regeneration in the median sections of the defects were measured 2, 4, and 8 weeks after surgical treatment. Our findings suggested that the weakly cross-linked atelocollagen matrix tends to demonstrate a scaffold of bone regeneration, and an appropriate dosage of bFGF may inhibit bone absorption to maintain the volume of the regenerated bone. © Springer-Verlag 2006.

引用

页码：517 / 522

页数：5

共 28 条

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