Characteristics of Epstein-Barr virus associated childhood non-Hodgkin’s lymphoma in the Republic of Korea

被引：0
作者：
DongHoon Kim
YoungHyeh Ko
Yeonlim Suh
HongHoe Koo
JooRyung Huh
WonKeun Lee
机构：
[1] Sungkyunkwan University School of Medicine,Department of Pathology, Samsung Medical Center
[2] Sungkyunkwan University School of Medicine,Department of Pediatrics, Samsung Medical Center
[3] University of Ulsan College of Medicine,Department of Pathology, Asan Medical Center
[4] Myongji University,Department of Biological Science
来源：
Virchows Archiv | 2005年 / 447卷
关键词：
Lymphoma; Anaplastic Large Cell Lymphoma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
To analyze the clinicopathologic characteristics of childhood non-Hodgkin’s lymphoma (NHL) associated with Epstein-Barr virus (EBV), EBER in situ hybridization was performed in 80 cases of NHLs. EBER-positive lymphomas account for 25% (20/80) and include NK/T-cell lymphoma (6/6), aggressive NK-cell leukemia (1/1), peripheral T cell lymphoma (5/11), diffuse large B-cell lymphoma (5/14), hydroa-like T-cell lymphoma (1/1), marginal zone B-cell lymphoma (1/2), and post-transplantation lymphoproliferative disorder (1/1). Other types including 19 cases of Burkitt’s lymphoma were negative. For 9 EBER-positive cases, immunohistochemical staining for LMP-1, and EBNA-2 was performed to determine the EBV latency pattern. Two of nine EBER-positive cases expressed both LMP-1 and EBNA-2. Clinically, patients with EBV-positive B-cell lymphomas were cured with chemotherapy, whereas EBV-associated NK- and T cell lymphomas pursued fatal clinical course. In conclusion, EBVs infected in childhood NHLs are frequently associated not only with NK- and T- cell lymphomas but also large B-cell lymphomas.
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页码：593 / 596
页数：3
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