Neurosyphilis

被引：54
作者：
Marra C.M. [1 ]
机构：
[1] Univ. of Washington Sch. of Medicine, Harborview Medical Center, Department of Neurology, Seattle, WA 98104-2499
来源：
Current Neurology and Neuroscience Reports | 2004年 / 4卷 / 6期
关键词：
Syphilis; Venereal Disease Research Laboratory; Secondary Syphilis; Early Syphilis; Treponema Pallidum Particle Agglutination;
D O I：
10.1007/s11910-004-0065-x
中图分类号：
学科分类号：
摘要：
Treponema pallidum, the bacterium that causes syphilis, invades the central nervous system early in the course of disease but causes persistent infection in only a subset of infected persons. Individuals with persistent infection or asymptomatic meningitis are at risk for developing symptomatic neurosyphilis if they are not treated with a drug regimen that achieves sufficient drug levels in cerebrospinal fluid to kill the organism. In this article, recent studies that address the risk, diagnosis, and management of neurosyphilis are discussed within the context of a brief review. Particular attention is given to current controversies. In the developed world, these issues are particularly relevant to persons who are infected with HIV. Copyright © 2004 by Current Science Inc.
引用
收藏
页码：435 / 440
页数：5
相关论文
共 44 条
[1]  
Golden M.R., Marra C.M., Holmes K.K., Update on syphilis: Resurgence of an old problem, JAMA, 290, pp. 1510-1514, (2003)
[2]  
Global prevalence and incidence of selected curable sexually transmitted infections: Overview and estimates, (2004)
[3]  
The World Health Report 2004 - Changing history, (2004)
[4]  
Primary and secondary syphilis - United States, 1999, MMWR Morb. Mortal. Wkly. Rep., 50, pp. 113-117, (2001)
[5]  
Primary and secondary syphilis - United States, 2000-2001, MMWR Morb. Mortal. Wkly. Rep., 51, pp. 971-973, (2002)
[6]  
Notice to readers: Final 2002 reports of notifiable diseases, MMWR Morb. Mortal. Wkly. Rep., 52, pp. 741-750, (2003)
[7]  
Primary and secondary syphilis - United States, 2002, MMWR Morb. Mortal. Wkly. Rep., 52, pp. 1117-1120, (2003)
[8]  
Kahn R.H., Heffelfinger J.D., Berman S.M., Syphilis outbreaks among men who have sex with men: A public health trend of concern, Sex. Transm. Dis., 29, pp. 285-287, (2002)
[9]  
Weir E., Fisman D., Fishman D., Syphilis: Have we dropped the ball?, Can. Med. Assoc. J., 167, pp. 1267-1268, (2002)
[10]  
Ashton M., Sopwith W., Clark P., Et al., An outbreak no longer: Factors contributing to the return of syphilis in Greater Manchester, Sex Transm. Infect., 79, pp. 291-293, (2003)
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