Advances in the pathogenesis of Alzheimer’s disease: a re-evaluation of amyloid cascade hypothesis

被引：0
作者：
Suzhen Dong
Yale Duan
Yinghe Hu
Zheng Zhao
机构：
[1] East China Normal University,Shanghai Engineering Research Center for Molecular Therapeutics and New Drug Development
[2] East China Normal University,Institute of Chemical and Translational Genomics
[3] East China Normal University,Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics
来源：
Translational Neurodegeneration | / 1卷 / 1期
关键词：
Alzheimer’s disease; A-beta; APP; BACE1; Presenilins; ApoE; Neprilysin/insulin-degrading enzyme;
D O I：
10.1186/2047-9158-1-18
中图分类号：
学科分类号：
摘要：
Alzheimer’s disease (AD) is a common neurodegenerative disease characterized clinically by progressive deterioration of memory, and pathologically by histopathological changes including extracellular deposits of amyloid-beta (A-beta) peptides forming senile plaques (SP) and the intracellular neurofibrillary tangles (NFT) of hyperphosphorylated tau in the brain. This review focused on the new developments of amyloid cascade hypothesis with details on the production, metabolism and clearance of A-beta, and the key roles of some important A-beta-related genes in the pathological processes of AD. The most recent research advances in genetics, neuropathology and pathogenesis of the disease were also discussed.
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[1]  
Möller HJ(1998)The case described by Alois Alzheimer in 1911 Eur Arch Psychiatry Clin Neurosci 248 111-122
[2]  
Graeber MB(2006)Alzheimer disease: progress or profit? Nat Med 12 780-784
[3]  
Mount C(1993)Incidence of dementia and probable Alzheimer’s disease in a general population: the Framingham Study Neurology 43 515-519
[4]  
Downton C(1997)The Alzheimer family of diseases: many etiologies, one pathogenesis? Proc Natl Acad Sci USA 94 2095-2097
[5]  
Bachman DL(1998)The pathogenesis of Alzheimer’s disease J Clin Psychiatry 59 7-14
[6]  
Wolf PA(2006)Alzheimer’s disease: the amyloid cascade hypothesis: an update and reappraisal J Alzheimers Dis 9 151-153
[7]  
Linn RT(1992)Alzheimer’s disease: the amyloid cascade hypothesis Science 256 184-185
[8]  
Knoefel JE(1994)Normal and abnormal biology of the beta-amyloid precursor protein Annu Rev Neurosci 17 489-517
[9]  
Cobb JL(2010)Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production J Biol Chem 285 32549-32556
[10]  
Belanger AJ(2005)Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2 J Neurosci 25 1219-1225
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