Growth hormone and aging

被引：0
作者：
Andrzej Bartke
机构：
[1] Southern Illinois University School of Medicine,
来源：
Reviews in Endocrine and Metabolic Disorders | 2021年 / 22卷
关键词：
GH excess; GH resistance; Growth hormone; Human aging; Lifespan; Healthspan; Mice;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Growth hormone (GH) actions impact growth, metabolism, and body composition and have been associated with aging and longevity. Lack of GH results in slower growth, delayed maturation, and reduced body size and can lead to delayed aging, increased healthspan, and a remarkable extension of longevity. Adult body size, which is a GH-dependent trait, has a negative association with longevity in several mammalian species. Mechanistic links between GH and aging include evolutionarily conserved insulin/insulin-like growth factors and mechanistic target of rapamycin signaling pathways in accordance with long-suspected trade-offs between anabolic/growth processes and longevity. Height and the rate and regulation of GH secretion have been related to human aging, but longevity is not extended in humans with syndromes of GH deficiency or resistance. However, the risk of age-related chronic disease is reduced in individuals affected by these syndromes and various indices of increased healthspan have been reported.
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页码：71 / 80
页数：9
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共 629 条
[1]  
Silberberg R(1972)Articular aging and osteoarthrosis in dwarf mice Pathol Microbiol (Basel) 38 417-430
[2]  
Brown-Borg HM(1996)Dwarf mice and the ageing process Nature 384 33-6741
[3]  
Borg KE(2001)Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production Proc Natl Acad Sci U S A 98 6736-533
[4]  
Meliska CJ(1990)Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1 Nature 347 528-333
[5]  
Bartke A(1996)Pituitary lineage determination by the prophet of Pit-1 homeodomain factor defective in Ames dwarfism Nature 384 327-2613
[6]  
Flurkey K(2000)Assessment of growth parameters and life span of GHR/BP gene-disrupted mice Endocrinology 141 2608-13220
[7]  
Papaconstantinou J(1997)A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse) Proc Natl Acad Sci U S A 94 13215-3810
[8]  
Miller RA(2003)Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span Endocrinology 144 3799-7905
[9]  
Harrison DE(2006)Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction Proc Natl Acad Sci U S A 103 7901-287
[10]  
Li S(2009)Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels Aging Cell 8 277-1764
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