Platelet-rich plasma and 1,25(OH)2 vitamin D3 synergistically stimulate osteogenic differentiation of adult human mesenchymal stem cells

被引：0
作者：
Yong Feng
Yuan Sun
Weitao Jia
Changqing Zhang
机构：
[1] Shanghai Jiaotong University,Department of Orthopaedics, The Sixth People’s Hospital
来源：
Biotechnology Letters | 2010年 / 32卷
关键词：
1,25-Dihydroxyvitamin D3; Mesenchymal stem cells; Osteogenic differentiation; Platelet-rich plasma; Proliferation;
D O I：
暂无
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学科分类号：
摘要：
Mesenchymal stem cell proliferation and differentiation are regulated by growth factors and systemic hormones in a concerted manner. We have examined the effects of platelet-rich plasma (PRP) and its interaction with 1,25(OH)2 vitamin D3 [1,25(OH)2D3] on the differentiation and proliferation of human mesenchymal stem cells (hMSCs). PRP stimulated cell proliferation in a manner inversely proportional to the dose. Exposure to PRP inhibited hMSC osteogenic differentiation. Co-treatment with PRP and 1,25(OH)2D3, however, synergistically stimulated osteogenic differentiation. Serial co-treatment with PRP and 1,25(OH)2D3 showed that this synergistic effect was due to the modulation of a 1,25(OH)2D3-induced differentiation by PRP rather than vice versa.
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页码：635 / 642
页数：7
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