Lobular neoplasms and invasive lobular breast cancer

被引:4
作者
Sinn, H. -P. [1 ]
Helmchen, B. [2 ]
Heil, J. [3 ]
Aulmann, S. [1 ]
机构
[1] Heidelberg Univ, Inst Pathol, D-69120 Heidelberg, Germany
[2] Stadtspital Triemli, Zurich, Switzerland
[3] Heidelberg Univ, Klin Frauenheilkunde, D-69120 Heidelberg, Germany
来源
PATHOLOGE | 2014年 / 35卷 / 01期
关键词
Lobular carcinoma in situ; Molecular characteristics; Variants; Prognosis estimation; Grading; CARCINOMA IN-SITU; PATHOLOGICAL PROGNOSTIC FACTORS; TERM FOLLOW-UP; INFILTRATING DUCT CARCINOMA; E-CADHERIN; TUBULOLOBULAR CARCINOMA; MAMMOGRAPHIC FINDINGS; METASTATIC PATTERNS; HISTOLOGICAL TYPE; BETA-CATENIN;
D O I
10.1007/s00292-013-1840-8
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The term lobular neoplasia (LN) comprises both atypical lobular hyperplasia (ALH), and lobular carcinoma in situ (LCIS) and thus a spectrum of morphologically heterogeneous but clinically and biologically related lesions. LN is regarded as a nonobligatory precursor lesion of invasive breast cancer and at the same time as an indicator lesion for ipsilateral and contralateral breast cancer risk of the patient. Rare pleomorphic or florid variants of LCIS must be differentiated from classical LCIS. The classical type of invasive lobular carcinoma (ILC) can be distinguished from the non-special type of invasive breast cancer (NST) by E-cadherin inactivation, loss of E-cadherin related cell adhesion and the subsequent discohesive growth pattern. Variant forms of ILC may show different molecular features, and solid and pleomorphic differentiation patterns in cases of high grade variants. Important parameters for the prognostic assessment of ILC are tumor grading and the recognition of morphological variants.
引用
收藏
页码:45 / 53
页数:9
相关论文
共 85 条
  • [1] ANDERSEN JA, 1974, ACTA PATH MICRO IM A, VA 82, P519
  • [2] Comparison of age distribution patterns for different histopathologic types of breast carcinoma
    Anderson, William F.
    Pfeiffer, Ruth M.
    Dores, Graca M.
    Sherman, Mark E.
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (10) : 1899 - 1905
  • [3] Clonality of lobular carcinoma in situ (LCIS) and metachronous invasive breast cancer
    Aulmann, Sebastian
    Penzel, Roland
    Longerich, Thomas
    Funke, Benjamin
    Schirmacher, Peter
    Sinn, Hans Peter
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2008, 107 (03) : 331 - 335
  • [4] The Florid Subtype of Lobular Carcinoma In Situ: Marker or Precursor for Invasive Lobular Carcinoma?
    Bagaria, Sanjay P.
    Shamonki, Jaime
    Kinnaird, Michelle
    Ray, Partha S.
    Giuliano, Armando E.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2011, 18 (07) : 1845 - 1851
  • [5] Lobular and ductal carcinomas of the breast have distinct genomic and expression profiles
    Bertucci, F.
    Orsetti, B.
    Negre, V.
    Finetti, P.
    Rouge, C.
    Ahomadegbe, J-C
    Bibeau, F.
    Mathieu, M-C
    Treilleux, I.
    Jacquemier, J.
    Ursule, L.
    Martinec, A.
    Wang, Q.
    Benard, J.
    Puisieux, A.
    Birnbaum, D.
    Theillet, C.
    [J]. ONCOGENE, 2008, 27 (40) : 5359 - 5372
  • [6] BORST MJ, 1993, SURGERY, V114, P637
  • [7] Lobular intraepithelial neoplasia: previously unexplored aspects assessed in 775 cases and their clinical implications
    Bratthauer, GL
    Tavassoli, FA
    [J]. VIRCHOWS ARCHIV, 2002, 440 (02) : 134 - 138
  • [8] Lobular Carcinoma, Not Only a Classic
    Brogi, Edi
    Murray, Melissa P.
    Corben, Adriana D.
    [J]. BREAST JOURNAL, 2010, 16 : S10 - S14
  • [9] Genetic and Phenotypic Characteristics of Pleomorphic Lobular Carcinoma In Situ of the Breast
    Chen, Yunn-Yi
    Hwang, Eun-Sil Shelley
    Roy, Ritu
    De Vries, Sandy
    Anderson, Joseph
    Wa, Chrystal
    Fitzgibbons, Patrick L.
    Jacobs, Timothy W.
    MacGrogan, Gaetan
    Peterse, Hans
    Vincent-Salomon, Anne
    Tokuyasu, Taku
    Schnitt, Stuart J.
    Waldman, Frederic M.
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2009, 33 (11) : 1683 - 1694
  • [10] Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma
    Choi, Young J.
    Pinto, Marguerite M.
    Hao, Liming
    Riba, Ali K.
    [J]. MODERN PATHOLOGY, 2008, 21 (10) : 1224 - 1237