Cross-species cluster co-conservation: a new method for generating protein interaction networks

被引：0
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作者：
Anis Karimpour-Fard
Corrella S Detweiler
Kimberly D Erickson
Lawrence Hunter
Ryan T Gill
机构：
[1] University of Colorado School of Medicine,Center for Computational Pharmacology
[2] University of Colorado,MCD
[3] University of Colorado,Biology
来源：
Genome Biology | / 8卷
关键词：
Additional Data File; Protein Interaction Network; Protein Pair; Phylogenetic Profile; Chemotaxis Protein;
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摘要：
Co-conservation (phylogenetic profiles) is a well-established method for predicting functional relationships between proteins. Several publicly available databases use this method and additional clustering strategies to develop networks of protein interactions (cluster co-conservation (CCC)). CCC has previously been limited to interactions within a single target species. We have extended CCC to develop protein interaction networks based on co-conservation between protein pairs across multiple species, cross-species cluster co-conservation.
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