Decrease of protein kinase C in the spinal motor neurons of amyotrophic lateral sclerosis

被引：0

作者：

M. Nagao

Shuichi Kato

Masaya Oda

Shunsaku Hirai

机构：

[1] Department of Neurology,

[2] Tokyo Metropolitan Neurological Hospital,undefined

[3] 2-6-1,undefined

[4] Musashidai,undefined

[5] Fuchu,undefined

[6] Tokyo 183-0042,undefined

[7] Japan Tel.: 81-423-23-5110; Fax: 81-423-22-6219,undefined

[8] Department of Neuropathology,undefined

[9] Tokyo Metropolitan Neurological Hospital,undefined

[10] Tokyo,undefined

[11] Japan,undefined

来源：

Acta Neuropathologica | 1998年 / 96卷

关键词：

Key words Calcium ion; Tyrosine kinase; Golgi; apparatus; Protein traffic; Axonal transport;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The expression of protein kinase C (PKC), a calcium- and phospholipid-dependent signaling molecule, was studied immunohistochemically in the spinal motor neurons of cases of sporadic amyotrophic lateral sclerosis (SALS). In the normal spinal cord, intense PKC immunoreactivity was found in subsets of large motor neurons. PKC immunoreactivity was markedly decreased in the spinal motor neurons of SALS. The result suggests that down-regulation of PKC is associated with the degeneration of spinal motor neurons in SALS.

引用

页码：52 / 56

页数：4