Synthesis and antiarrhythmic activity of quaternary derivatives and mineral salts of diethylaminoacetic acid ortho-toluidide

被引：2

作者：

Gashkova O.V. ^{[1
]}

Pantsurkin V.I. ^{[1
]}

Rudakova I.P. ^{[1
]}

Syropyatov B.J. ^{[1
]}

Vahrin M.I. ^{[1
]}

机构：

[1] Perm State Pharmaceutical Academy, Perm

来源：

Pharmaceutical Chemistry Journal | 2008年 / 42卷 / 12期

关键词：

Lidocaine; Acute Toxicity; Mineral Salt; Pure Product; Antiarrhythmic Activity;

D O I：

10.1007/s11094-009-0217-z

中图分类号：

学科分类号：

摘要：

A series of quaternary dervatives of diethylaminoacetic acid ortho-toluidide have been synthesized by reactions with various halogen-containing derivatives of alkanes, alkenes, and arylalkanes in acetone. The acute toxicity and antiarrhythmic activity of the synthesized compounds have been studied. Several compounds with antiarrhythmic activity exceeding that of a structural analog (lidocaine) are found and recommended for further investigation and practical implementation. © 2008 Springer Science+Business Media, Inc.

引用

页码：665 / 667

页数：2

共 11 条

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