Pre-operative chemotherapy for colorectal cancer liver metastases: an update of recent clinical trials

被引:0
|
作者
G. Nasti
A. Ottaiano
M. Berretta
P. Delrio
F. Izzo
A. Cassata
C. Romano
G. Facchini
D. Scala
A. Mastro
G. Romano
F. Perri
R. V. Iaffaioli
机构
[1] National Cancer Institute of Naples,Department of Colorectal Medical Oncology
[2] National Cancer Institute of Aviano,Department of Medical Oncology
[3] National Cancer Institute of Naples,Colorectal Department, Surgery Unit
[4] National Cancer Institute of Naples,Epato
来源
Cancer Chemotherapy and Pharmacology | 2010年 / 66卷
关键词
Liver metastases; Colorectal cancer; Neoadjuvant; Resection;
D O I
暂无
中图分类号
学科分类号
摘要
The standard treatment of CRC patients with hepatic metastases is systemic chemotherapy; however, 5-year survival is disappointingly poor despite recent advances. On the other hand, in patients who undergo immediate radical surgical resection of hepatic metastases, 5-year survival reaches 30–40%. Unfortunately, only 15–20% of patients with hepatic metastases are initially eligible for a radical surgical approach. The majority of patients undergoing liver resection relapse after surgery. For this reason, new onco-surgery approaches have been investigated in recent years and the addition of biological agents to chemotherapy, such as bevacizumab and cetuximab, and the improvements of surgical techniques have opened a new scenario in the management of colorectal liver metastases. Recently, the EORTC trial has demonstrated that perioperative chemotherapy (Folfox regimen) is feasible and improves progression-free survival in patients with resectable liver metatsases. Chemotherapy and surgery can finally collaborate. In the unresectable setting, the association of chemotherapy with bevacizumab and cetuximab is particularly promising in improving resectability rate. In particular, K-RAS is a molecular response predictive factor that could be particularly useful in selecting the best treatment option in patients with unresectable liver disease.
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页码:209 / 218
页数:9
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