The role of leptin in innate and adaptive immune responses

被引：0
作者：
Eiva Bernotiene
Gaby Palmer
Cem Gabay
机构：
[1] Institute of Experimental and Clinical Medicine,Department of Experimental Research
[2] Vilnius University,Division of Rheumatology, Department of Internal Medicine
[3] University Hospital,Department of Pathology and Immunology
[4] University of Geneva School of Medicine,undefined
来源：
Arthritis Research & Therapy | / 8卷
关键词：
Rheumatoid Arthritis Patient; Experimental Autoimmune Encephalomyelitis; Innate Immune Response; Arthus Reaction; Lean Littermate;
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摘要：
Leptin is produced primarily by adipocytes and functions in a feedback loop regulating body weight. Leptin deficiency results in severe obesity and a variety of endocrine abnormalities in animals and humans. Several studies indicated that leptin plays an important role in immune responses. It exerts protective anti-inflammatory effects in models of acute inflammation and during activation of innate immune responses. In contrast, leptin stimulates T lymphocyte responses, thus having rather a proinflammatory role in experimental models of autoimmune diseases. Clinical studies have so far yielded inconsistent results, suggesting a rather complex role for leptin in immune-mediated inflammatory conditions in humans.
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