Neuronal activity in the substantia nigra in the anaesthetized rat has fractal characteristics. Evidence for firing-code patterns in the basal ganglia

被引：0
作者：
M. Rodríguez
E. Pereda
J. González
P. Abdala
J. A. Obeso
机构：
[1] University of La Laguna,Department of Physiology, Faculty of Medicine
[2] University of La Laguna,Department of Basic Physics, Faculty of Physics
[3] University of Navarra,Neuroscience Centre, Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School
来源：
Experimental Brain Research | 2003年 / 151卷
关键词：
Fractal; Substantia nigra; Basal ganglia; GABA cell; Dopamine cell;
D O I：
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中图分类号：
学科分类号：
摘要：
Current models of the basal ganglia assume a firing-rate code for information processing. We have applied five complementary computing methods to assess firing patterns in 188 cells of the substantia nigra in the anaesthetized rat. Fractal firing activity was found in 100% of nigral cells projecting to the superior colliculus, in 51% of cells projecting to the thalamus and in 33% of cells projecting to the pedunculopontine nucleus, but was practically absent in dopaminergic nigrostriatal neurons (3%). The finding of fractal firing patterns may lead to a better understanding of the normal operational mode and pathological manifestations of the basal ganglia.
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页码：167 / 172
页数：5
相关论文
共 43 条
  • [1] Alexander JA(1986)Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model Annu Rev Neurosci 9 357-34
  • [2] Allan MC(1966)Fractal character of the neural spike train in the visual system of the cat IEEE 54 221-546
  • [3] Fano M(1947)undefined Phys Rev 72 26-undefined
  • [4] Farmer MR(2002)undefined Brain 125 1175-undefined
  • [5] Faure W(1997)undefined Proc Natl Acad Sci USA 94 6506-undefined
  • [6] Garcia-Baez MC(1998)undefined J Neurosci Methods 82 59-undefined
  • [7] Gerfen C(1990)undefined Science 250 1429-undefined
  • [8] Goldberger SB(1996)undefined Lancet 347 1312-undefined
  • [9] Goldberger T(1990)undefined Sci Am 262 42-undefined
  • [10] Gonon E(1988)undefined Neuroscience 24 19-undefined
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