A Perfused In Vitro Human iPSC-Derived Blood–Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies

[1] Appelt-Menzel A(2017)Establishment of a human blood-brain barrier co-culture model mimicking the neurovascular unit using induced pluri- and multipotent stem cells Stem Cell Rep 8 894-906

[2] Cubukova A(2015)Recreating blood-brain barrier physiology and structure on chip: a novel neurovascular microfluidic bioreactor Biomicrofluidics 9 054124-888

[3] Günther K(2017)An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells J Neurochem 140 874-94

[4] Brown JA(2022)Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance Nat Protoc 17 76-135

[5] Pensabene V(2011)The role of shear stress in Blood-Brain Barrier endothelial physiology BMC Neurosci 12 40-1327

[6] Markov DA(2019)Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting Adv Drug Deliv Rev 140 129-890

[7] Canfield SG(2017)Non-invasive approaches for drug delivery to the brain based on the receptor mediated transport Mater Sci Eng C 76 1316-1547

[8] Stebbins MJ(2014)A novel platform for engineering blood-brain barrier-crossing bispecific biologics FASEB J 286 121525-37

[9] Morales BS(2022)Human iPSC-derived brain endothelial microvessels in a multi-well format enable permeability screens of anti-inflammatory drugs Biomaterials 36 862-1532

[10] Chu C(2016)In vitro models of the blood–brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use J Cereb Blood Flow Metab 16 15-791

[1] Appelt-Menzel A(2017)Establishment of a human blood-brain barrier co-culture model mimicking the neurovascular unit using induced pluri- and multipotent stem cells Stem Cell Rep 8 894-906

[2] Cubukova A(2015)Recreating blood-brain barrier physiology and structure on chip: a novel neurovascular microfluidic bioreactor Biomicrofluidics 9 054124-888

[3] Günther K(2017)An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells J Neurochem 140 874-94

[4] Brown JA(2022)Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance Nat Protoc 17 76-135

[5] Pensabene V(2011)The role of shear stress in Blood-Brain Barrier endothelial physiology BMC Neurosci 12 40-1327

[6] Markov DA(2019)Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting Adv Drug Deliv Rev 140 129-890

[7] Canfield SG(2017)Non-invasive approaches for drug delivery to the brain based on the receptor mediated transport Mater Sci Eng C 76 1316-1547

[8] Stebbins MJ(2014)A novel platform for engineering blood-brain barrier-crossing bispecific biologics FASEB J 286 121525-37

[9] Morales BS(2022)Human iPSC-derived brain endothelial microvessels in a multi-well format enable permeability screens of anti-inflammatory drugs Biomaterials 36 862-1532

[10] Chu C(2016)In vitro models of the blood–brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use J Cereb Blood Flow Metab 16 15-791