Epigenetics in cancer stem cells

被引：0
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作者：
Tan Boon Toh
Jhin Jieh Lim
Edward Kai-Hua Chow
机构：
[1] National University of Singapore,Cancer Science Institute of Singapore
[2] National University of Singapore,Department of Pharmacology, Yong Loo Lin School of Medicine
[3] National University of Singapore,Centre for Translational Medicine
来源：
Molecular Cancer | / 16卷
关键词：
Cancer stem cells; Epigenetics; Histone methylation; Histone methyltransferase; DNA methylation; Signaling pathway;
D O I：
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摘要：
Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key mechanism of therapeutic resistance. Recent advances in epigenomics have illuminated key mechanisms by which epigenetic regulation contribute to cancer progression. In this review, we present a discussion of how deregulation of various epigenetic pathways can contribute to cancer initiation and tumorigenesis, particularly with respect to maintenance and survival of cancer stem cells. This information, together with several promising clinical and preclinical trials of epigenetic modulating drugs, offer new possibilities for targeting cancer stem cells as well as improving cancer therapy overall.
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