Wound healing potential of chitosan and N-sulfosuccinoyl chitosan derivatives

被引:0
作者
T. P. Alekseeva
A. A. Rakhmetova
O. A. Bogoslovskaya
I. P. Olkhovskaya
A. N. Levov
A. V. Il’ina
V. P. Varlamov
T. A. Baitukalov
N. N. Glushchenko
机构
[1] Russian Academy of Science,Institute of Energy Problems of Chemical Physics
[2] Peoples’ Friendship University of Russia,Center Bioinzeneria
[3] Russian Academy of Science,undefined
[4] Familiprix Lasalle,undefined
来源
Biology Bulletin | 2010年 / 37卷
关键词
Chitosan; Wound Healing; Chitin; Biology Bulletin; Maleic Anhydride;
D O I
暂无
中图分类号
学科分类号
摘要
Comparative study of chitosan wound healing properties and its synthesized derivatives in MC-100 gel was carried out using the model of experimental full thickness skin wounds. It was determined that N-sulfosuccinoyl chitosan derivatives added into the gel in a concentration of 0.05% possess the higher wound healing activity in comparison with other chitosan derivatives and decrease the half-healing period of wounds 2–3 times in comparison with the control.
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页码:339 / 345
页数:6
相关论文
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[1]  
Alves N.M.(2008)Chitosan Derivatives Obtained by Chemical Modifications for Biomedical and Environmental Applications Int. J. Biol. Macromol. 43 401-414
[2]  
Mano J.F.(2005)Regenerating Activity and Antibacterial Effect of Low-Molecular-Weight Chitosan Izv. Akad. Nauk, Ser. Biol. 32 659-663
[3]  
Baytukalov T.A.(1991)Wound Management with Biomaterials 12 281-285
[4]  
Bogoslovskaya O.A.(2004)-Carboxybutil Chitosan Chromatografia 59 709-713
[5]  
Olkhovskaya I.P.(2003)-(3-Sulfo, 3-Carboxy)-Propionylchitosan as New Chiral Selector for Enantioresolution of Basic Drugs by Capillary Electrophoresis Biochem. Biophys. Res. Commun. 308 403-407
[6]  
Biagini G.(2009)Chitosan Inhibits Prostaglandin E2 Formation and Cyclooxygenase-2 Induction in Lipopolysaccharide-Treated RAW 264.7 Macrophages Antimicrob. Agents Chemother. 53 393-400
[7]  
Bertani A.(1985)Chitosan Acetate Bandage as a Topical Antimicrobial Dressing for Infected Burns Acta. Polym. 36 421-424
[8]  
Budanova N.(1991)Investigation of the Hydrodynamic Properties of Chitosan Solutions Polym. Bull. 26 87-94
[9]  
Shapovalova E.(2003)Determination of Degree of Deacetylation of Chitosan by 1H NMR Spectroscopy Prikl. Biokhim. Mikrobiol. 39 273-277
[10]  
Lopatin S.(2001)Effect of the Degree of Acetylation on the Enzymatic Hydrolysis of Chitosan by the Preparation Celloviridin G20H J. Chitin Chitosan 6 163-167