Synthesis of 99mTc-Radiolabeled Uridine as a Potential Tumor Imaging Agent

被引:1
|
作者
Talaat H.M. [1 ]
Ibrahim I.T. [1 ]
Bayomy N.A. [1 ]
Farouk N. [1 ]
机构
[1] Hot Laboratories Centre, Atomic Energy Authority, P.O. Box 13759, Cairo
关键词
radiopharmaceuticals; technetium-99m; tumor imaging; uridine;
D O I
10.1134/S1066362218010095
中图分类号
学科分类号
摘要
Uridine, a pyrimidine nucleoside essential for the synthesis of RNA and biomembranes, was radiolabeled with 99mTc to obtain a potential tumor imaging agent. The maximal radiochemical yield of about 96.5%, as determined by paper chromatography and instant thin-layer chromatography, was reached under the following optimum conditions: 1 mg of uridine, 20 μg of SnCl2·2H2O as reducing agent, 20 mg of mannitol as a stabilizer, and pH 8. 99mTc-uridine is stable in vitro at room temperature for up to 6 h post labeling. The biodistrbution study in tumor-bearing mice shows high target-to-nontarget ratio. These results match with the high docking score of the complex on uridine phosphorylase enzyme. 99mTc-uridine shows promise as a tumor imaging agent. © 2018, Pleiades Publishing, Inc.
引用
收藏
页码:51 / 57
页数:6
相关论文
共 50 条
  • [41] Synthesis and biodistribution of a novel 99mTc complex of HYNIC-Conjugated thymidine as a potential tumor imaging agent
    Liu Liqin
    Wang Junwei
    Wei Yaqian
    Zhao Manchen
    Liu Lirui
    Wang Xuebin
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2013, 56 : S348 - S348
  • [42] Preparation and characterization of 99mTc radiolabeled glycosylated somatostatin as potential imaging agent for somatostatin receptor positive tumours
    He, C.
    Zhai, S.
    Shen, Y.
    Hu, C.
    Zhao, L.
    Cui, H.
    Du, J.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2006, 33 : S307 - S307
  • [43] Development and evaluation of 99mTc-labeled LHRH peptide as potential tumor imaging agent
    Camacho, Ximena
    Cabrera, Mirel
    Alfaya, Lucia
    Garcia, Maria Fernanda
    Lecot, Nicole
    Fernandez, Marcelo
    Gambini, Juan
    Cabral, Pablo
    JOURNAL OF NUCLEAR MEDICINE, 2017, 58
  • [44] 99mTc(CO)3–AOPA colchicine conjugate as a potential tumor imaging agent
    Jianjun Wang
    Xiaojiang Duan
    Huining Mao
    Jing Yang
    Tingting Niu
    Journal of Radioanalytical and Nuclear Chemistry, 2011, 288 : 635 - 639
  • [45] Synthesis of Technidazole: a potential new 99mTc ligand for imaging tumor hypoxia
    Joyard, Y. M.
    Bohn, P.
    Papamicael, C.
    Levacher, V.
    Vera, P.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 : S413 - S413
  • [46] Synthesis and evaluation of a 99mTc-labeled tubulin-binding agent for tumor imaging
    Erfani, Mostafa
    Shamsaei, Mojtaba
    Mohammadbaghery, Faiyaz
    Shirmardi, Seyed Pezhman
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2014, 57 (06): : 419 - 424
  • [47] Pharmacokinetic Evaluation of 99mTc-radiolabeled Solid Lipid Nanoparticles and Chitosan Coated Solid Lipid Nanoparticles
    Gharibkandi, Nasrin Abbasi
    Molavipordanjani, Sajjad
    Akbari, Jafar
    Hosseinimehr, Seyed Jalal
    CURRENT DRUG METABOLISM, 2019, 20 (13) : 1044 - 1052
  • [48] Synthesis and evaluation of a 99mTc-labeled deoxyglucose derivative as a potential agent to target tumor
    Wang, Yue
    Song, Xiaoqing
    Zhang, Junbo
    JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2015, 306 (02) : 477 - 482
  • [49] Synthesis and evaluation of a 99mTc-labeled deoxyglucose derivative as a potential agent to target tumor
    Yue Wang
    Xiaoqing Song
    Junbo Zhang
    Journal of Radioanalytical and Nuclear Chemistry, 2015, 306 : 477 - 482
  • [50] Synthesis and biodistribution of a novel 99mTc complex of HYNIC-conjugated metronidazole as a potential tumor hypoxia imaging agent
    Liu, Liqin
    Zhang, Min
    Zhong, Guangrong
    Wang, Xuebin
    JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2011, 287 (03) : 847 - 852