Nuclear survivin as a biomarker for non-small-cell lung cancer

被引：0

作者：

B Lu

A Gonzalez

P P Massion

Y Shyr

B Shaktour

D P Carbone

D E Hallahan

机构：

[1] Vanderbilt Ingram,Department of Radiation Oncology

[2] Cancer Center,Department of Pathology

[3] Vanderbilt University School of Medicine,Department of Medicine

[4] Vanderbilt Ingram,Department of Preventive Medicine

[5] Cancer Center,undefined

[6] Vanderbilt University School of Medicine,undefined

[7] Vanderbilt Ingram,undefined

[8] Cancer Center,undefined

[9] Vanderbilt University School of Medicine,undefined

[10] Vanderbilt Ingram,undefined

[11] Cancer Center,undefined

[12] Vanderbilt University School of Medicine,undefined

来源：

British Journal of Cancer | 2004年 / 91卷

关键词：

survivin; lung cancer; nucleus; tissue array; mitosis; apoptosis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P=0.02). Therefore, survivin may be a biomarker for NSCLC.

引用

页码：537 / 540

页数：3

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