Nuclear survivin as a biomarker for non-small-cell lung cancer

被引：0
作者：
B Lu
A Gonzalez
P P Massion
Y Shyr
B Shaktour
D P Carbone
D E Hallahan
机构：
[1] Vanderbilt Ingram,Department of Radiation Oncology
[2] Cancer Center,Department of Pathology
[3] Vanderbilt University School of Medicine,Department of Medicine
[4] Vanderbilt Ingram,Department of Preventive Medicine
[5] Cancer Center,undefined
[6] Vanderbilt University School of Medicine,undefined
[7] Vanderbilt Ingram,undefined
[8] Cancer Center,undefined
[9] Vanderbilt University School of Medicine,undefined
[10] Vanderbilt Ingram,undefined
[11] Cancer Center,undefined
[12] Vanderbilt University School of Medicine,undefined
来源：
British Journal of Cancer | 2004年 / 91卷
关键词：
survivin; lung cancer; nucleus; tissue array; mitosis; apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P=0.02). Therefore, survivin may be a biomarker for NSCLC.
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收藏
页码：537 / 540
页数：3
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