Fibronectin as a multiregulatory molecule crucial in tumor matrisome: from structural and functional features to clinical practice in oncology

被引：0

作者：

Sheila Spada

Annalisa Tocci

Francesca Di Modugno

Paola Nisticò

机构：

[1] Weill Cornell Medicine,Department of Radiation Oncology

[2] Tumor Immunology and Immunotherapy Unit,undefined

[3] IRCCS-Regina Elena National Cancer Institute,undefined

来源：

Journal of Experimental & Clinical Cancer Research | / 40卷

关键词：

Fibronectin; Fibrillogenesis; Extracellular matrix; Actin cytoskeleton; Cancer-associated fibroblasts; Metastasis; Dormant cells; Metastatic niche; Extracellular vesicles; Cancer;

D O I：

暂无

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学科分类号：

摘要：

Deciphering extracellular matrix (ECM) composition and architecture may represent a novel approach to identify diagnostic and therapeutic targets in cancer. Among the ECM components, fibronectin and its fibrillary assembly represent the scaffold to build up the entire ECM structure, deeply affecting its features. Herein we focus on this extraordinary protein starting from its complex structure and defining its role in cancer as prognostic and theranostic marker.

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