A comparative study of hepatoprotective effect of Inula britannica L aqueous extract and glibenclamide in streptozotocin-induced diabetic mice

被引：6
作者：
Zangeneh M.M. [1 ,2 ]
Zangeneh A. [1 ,2 ]
Almasi M. [1 ]
Tahvilian R. [2 ]
Hosseini F. [2 ]
Moradi R. [2 ]
机构：
[1] Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Kermanshah
[2] Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah
来源：
Comparative Clinical Pathology | 2018年 / 27卷 / 6期
关键词：
Diabetes; Hepatotoxicity; Inula britannica L; Streptozotocin;
D O I：
10.1007/s00580-018-2789-z
中图分类号：
学科分类号：
摘要：
Inula britannica L. has been used in medicine as a theraputical agent. The aim of the present study was to assess the hepatoprotective property of I. britannica aqueous extract against streptozotocin (STZ)-induced diabetes in mice. In this study, 60 mice were used. Diabetes was experimentally induced by injection of STZ in 50 mice. The levels of blood glucose were evaluated by glucometer strips. Mice with plasma glucose level more than 250 mg/dL were considered diabetic. After 3 days, they were divided randomly into six groups. Groups 1 and 2 served as non-diabetic and untreated diabetic controls, respectively. Group 3 received 30 mg/kg glibenclamide orally. Groups 4, 5, and 6 were given 30, 90, and 270 mg/kg, respectively, of I. britannica for 20 days orally. At 20th day, the mice were dissected; blood and liver samples collected for hematological, biochemical, and histological parameter analysis. Hematologically, I. britannica and glibenclamide could reduce significantly (p ≤ 0.05) the raised levels of WBC, platelet, and increased RBC number as compared to the untreated group. Biochemically, I. britannica at all dose (especially IB270) and glibenclamide could significantly (p ≤ 0.05) reduce the raised levels of glucose, ALP, AST, ALT, cholesterol, LDL, and increased HDL, SOD, and CAT levels as compared to the untreated group. Histologically, different doses of I. britannica (especially IB270) similar to glibenclamide could significantly (p ≤ 0.05) decreased the volume of the liver structures as compared to the untreated group. It concluded that I. britannica could ameliorate hyperglycemia and improved hepatic changes following diabetes in STZ-induced diabetic mice. So, according to these features, it could be used as an antidiabetic supplement or drug. © 2018, Springer-Verlag London Ltd., part of Springer Nature.
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页码：1649 / 1657
页数：8
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