A parallel-group, multicenter randomized, double-blinded, placebo-controlled, phase 2/3, clinical trial to test the efficacy of pyridostigmine bromide at low doses to reduce mortality or invasive mechanical ventilation in adults with severe SARS-CoV-2 infection: the Pyridostigmine In Severe COvid-19 (PISCO) trial protocol

被引：0
作者：
Sergio Fragoso-Saavedra
David A. Iruegas-Nunez
Alejandro Quintero-Villegas
H. Benjamín García-González
Isaac Nuñez
Sergio L. Carbajal-Morelos
Belem M. Audelo-Cruz
Sarahi Arias-Martínez
Yanink Caro-Vega
Juan José Calva
Verónica Luqueño-Martínez
Alejandra González-Duarte
Brenda Crabtree-Ramírez
José C. Crispín
Juan Sierra-Madero
Pablo F. Belaunzarán-Zamudio
Sergio I. Valdés-Ferrer
机构：
[1] Universidad Nacional Autónoma de Mexico,Programa de Estudios Combinados en Medicina (MD/PhD program)
[2] Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán,Departamento de Neurología
[3] Escuela Nacional de Medicina y Ciencias de la Salud,Internal Medicine Residency Training Program
[4] Instituto Tecnológico y de Destudios Superiores de Monterrey,Departamento de Infectología
[5] Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán,Departamento de e Inmunología y Reumatología
[6] Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán,Division of AIDS, National Institute of Allergy and Infectious Diseases
[7] Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán,Center for Biomedical Science
[8] National Institutes of Health,undefined
[9] Feinstein Institute for Medical Research,undefined
来源：
BMC Infectious Diseases | / 20卷
关键词：
COVID-19; SARS-Cov-2; Mortality; Invasive mechanical ventilation; Immunomodulation; Pyridostigmine; ACh; Inflammatory reflex; Placebo-controlled trial;
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