Abnormal skin barrier in the etiopathogenesis of atopic dermatitis

被引：0
作者：
Peter M. Elias
Matthias Schmuth
机构：
[1] VA Medical Center,Dermatology Service (190)
来源：
Current Allergy and Asthma Reports | 2009年 / 9卷
关键词：
Atopic Dermatitis; Dermatol; Stratum Corneum; Allergy Clin Immunol; Psoriasin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Prior studies revealed the key roles played by T-helper type 1 and type 2 (Th1/Th2) cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling in the evolution of the chronic, pruritic, inflammatory dermatosis that characterizes atopic dermatitis (AD). Accordingly, current therapy has been largely directed toward ameliorating Th2-mediated inflammation and pruritus. This article reviews emerging evidence that the inflammation in AD results from inherited and acquired insults to the barrier, as well as the therapeutic implications of this new paradigm.
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页码：265 / 272
页数：7
相关论文
共 184 条
[31]  
Di Nardo A.(2008)Atopic dermatitis N Engl J Med 358 1483-1494
[32]  
Gallo R.L.(2008)Filaggrin in atopic dermatitis J Allergy Clin Immunol 122 689-693
[33]  
Oren A.(2007)Filaggrin’s fuller figure: a glimpse into the genetic architecture of atopic dermatitis J Invest Dermatol 127 1282-1284
[34]  
Ganz T.(1983)The characterization of human epidermal filaggrin. A histidine-rich, keratin filament-aggregating protein Biochim Biophys Acta 744 28-35
[35]  
Liu L.(1983)Histidine-rich proteins (filaggrins): structural and functional heterogeneity during epidermal differentiation J Mol Biol 170 651-673
[36]  
Meerloo T.(1985)Profilaggrin, a high-molecular-weight precursor of filaggrin in human epidermis and cultured keratinocytes J Invest Dermatol 85 507-512
[37]  
Walley A.J.(1996)Filaggrin linker segment peptide and cystatin alpha are parts of a complex of the cornified envelope of epidermis Arch Biochem Biophys 329 123-126
[38]  
Chavanas S.(1995)The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope J Biol Chem 270 17702-17711
[39]  
Moffatt M.F.(1982)Histidine-rich protein of the keratohyalin granules. Source of the free amino acids, urocanic acid and pyrrolidone carboxylic acid in the stratum corneum Biochim Biophys Acta 719 110-117
[40]  
Hachem J.P.(1994)Stratum corneum moisturization at the molecular level J Invest Dermatol 103 731-741
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