Abnormal skin barrier in the etiopathogenesis of atopic dermatitis

被引：0
作者：
Peter M. Elias
Matthias Schmuth
机构：
[1] VA Medical Center,Dermatology Service (190)
来源：
Current Allergy and Asthma Reports | 2009年 / 9卷
关键词：
Atopic Dermatitis; Dermatol; Stratum Corneum; Allergy Clin Immunol; Psoriasin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Prior studies revealed the key roles played by T-helper type 1 and type 2 (Th1/Th2) cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling in the evolution of the chronic, pruritic, inflammatory dermatosis that characterizes atopic dermatitis (AD). Accordingly, current therapy has been largely directed toward ameliorating Th2-mediated inflammation and pruritus. This article reviews emerging evidence that the inflammation in AD results from inherited and acquired insults to the barrier, as well as the therapeutic implications of this new paradigm.
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页码：265 / 272
页数：7
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[1]  
Sugarman J.L.(2003)The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease Arch Dermatol 139 1417-1422
[2]  
Fluhr J.W.(1995)Objective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin Acta Derm Venereol 75 429-433
[3]  
Fowler A.J.(2006)Skin barrier function, epidermal proliferation and differentiation in eczema J Dermatol Sci 43 159-169
[4]  
Seidenari S.(2002)Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity J Am Acad Dermatol 47 198-208
[5]  
Giusti G.(2006)The role of microorganisms in atopic dermatitis Clin Exp Immunol 144 1-9
[6]  
Proksch E.(1999)Epidermal pathogenesis of inflammatory dermatoses Am J Contact Dermat 10 119-126
[7]  
Folster-Holst R.(2001)Does the tail wag the dog? Role of the barrier in the pathogenesis of inflammatory dermatoses and therapeutic implications Arch Dermatol 137 1079-1081
[8]  
Jensen J.M.(1999)Hypothesis: from epidermal barrier dysfunction to atopic disorders Contact Dermatitis 41 177-180
[9]  
Chamlin S.L.(2007)The steroid-sparing effect of an emollient therapy in infants with atopic dermatitis: a randomized controlled study Dermatology 214 61-67
[10]  
Kao J.(2005)Stratum corneum defensive functions: an integrated view J Invest Dermatol 125 183-200
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