Abnormal skin barrier in the etiopathogenesis of atopic dermatitis

被引：0
|
作者：
Peter M. Elias
Matthias Schmuth
机构：
[1] VA Medical Center,Dermatology Service (190)
来源：
Current Allergy and Asthma Reports | 2009年 / 9卷
关键词：
Atopic Dermatitis; Dermatol; Stratum Corneum; Allergy Clin Immunol; Psoriasin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Prior studies revealed the key roles played by T-helper type 1 and type 2 (Th1/Th2) cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling in the evolution of the chronic, pruritic, inflammatory dermatosis that characterizes atopic dermatitis (AD). Accordingly, current therapy has been largely directed toward ameliorating Th2-mediated inflammation and pruritus. This article reviews emerging evidence that the inflammation in AD results from inherited and acquired insults to the barrier, as well as the therapeutic implications of this new paradigm.
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页码：265 / 272
页数：7
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