Propranolol for Infantile Hemangiomas: A Review

被引：2
作者：
Hogeling M. [1 ]
机构：
[1] Department of Dermatology, Phoenix Children's Hospital, Phoenix, AZ, 85016
来源：
Current Dermatology Reports | 2012年 / 1卷 / 4期
关键词：
Adverse effects; Airway hemangioma; Hepatic hemangioma; Infantile hemangioma; PHACE syndrome; Propranolol; Topical beta blockers; Ulcerated hemangioma;
D O I：
10.1007/s13671-012-0026-6
中图分类号：
学科分类号：
摘要：
Infantile hemangiomas (IHs) are the most common vascular tumors of infancy. Since it was discovered several years ago, propranolol hydrochloride has become a very popular and successful treatment for complicated and aesthetically disfiguring IHs. The recent literature on propranolol is reviewed, including a summary of larger studies, discussion of adverse effects, and the use of propranolol in complicated IHs, such as ulcerated IHs, airway, and hepatic IHs. © 2012 Springer Science+Business Media, LLC.
引用
收藏
页码：179 / 185
页数：6
相关论文
共 46 条
[1]  
Frieden I.J., Haggstrom A.N., Drolet B.A., Et al., Infantile hemangiomas: current knowledge, future directions. Proceedings of a research workshop on infantile hemangiomas. April 7-9, 2005. Bethesda, Maryland, Pediatr Dermatol., 22, 5, pp. 383-406, (2005)
[2]  
Tollefson M.M., Frieden I.J., Early growth of infantile hemangiomas: what parents' photographs tell us, Pediatrics, (2012)
[3]  
Chang L.C., Haggstrom A.N., Drolet B.A., Et al., Growth characteristics of infantile hemangiomas: implications for management, Pediatrics., 122, 2, pp. 360-367, (2008)
[4]  
Leaute-Labreze C., Dumas de la Roque E., Hubiche T., Et al., Propranolol for severe hemangiomas of infancy, N Engl J Med., 358, 24, pp. 2649-2651, (2008)
[5]  
Hogeling M., Adams S., Wargon O., A randomized controlled trial of propranolol for infantile hemangiomas, Pediatrics, 128, 2, (2011)
[6]  
Starkey E., Shahidullah H., Propranolol for infantile haemangiomas: a review, Arch Dis Child, 96, pp. 860-893, (2011)
[7]  
Lalonde R.L., Pieper J.A., Straka R.J., Et al., Propranolol pharmacokinetics and pharmacodynamics after single doses and at steady-state, Eur J Clin Pharmacol., 32, pp. 315-318, (1987)
[8]  
Storch C.H., Hoeger P.H., Propranolol for infantile haemangiomas: insights into the molecular mechanisms of action, Br J Dermatol, 168, 2, pp. 269-274, (2010)
[9]  
Greenberger S., Bischoff J., Infantile hemangioma-mechanism(s) of drug action on a vascular tumor, Cold Spring Harb Perspect Med., 1, 1, (2011)
[10]  
Chim H., Armijo B.S., Miller E., Et al., Propranolol induces regression of hemangioma cells through HIF-1α mediated inhibition of VEGF-A, Ann Surg., (2012)
12345