4-Hydroxy-2-quinolones 120. Synthesis and structure of ethyl 2-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylate

被引：0
|
作者：
Ukrainets I.V. [1 ]
Bereznyakova N.L. [1 ]
Petyunin G.P. [1 ]
Tugaibei I.A. [1 ]
Rybakov V.B. [2 ]
Chernyshev V.V. [2 ]
Turov A.V. [3 ]
机构：
[1] National University of Pharmacy
[2] M. V. Lomonosov Moscow State University
[3] Taras Shevchenko National University
来源：
Chemistry of Heterocyclic Compounds | 2007年 / 43卷 / 6期
关键词：
2-aminopyridines; 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids; Esters; Heterocyclic tricarbonylmethane derivatives; X-ray analysis;
D O I：
10.1007/s10593-007-0119-5
中图分类号：
学科分类号：
摘要：
An improved method for the preparation and purification of ethyl 2-hydroxy-4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carboxylates is proposed. According to 1H and 13C NMR spectroscopic data the synthesized compounds exist in DMSO solution in the 2-hydroxy-4-oxo form while in the crystal (at least for the case of the unsubstituted derivative) X-ray analysis shows that it occurs in the bipolar 2,4-dioxo form. © 2007 Springer Science+Business Media, Inc.
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页码：729 / 739
页数：10
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