4-Hydroxy-2-quinolones 120. Synthesis and structure of ethyl 2-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylate

被引：0

作者：

Ukrainets I.V. ^{[1
]}

Bereznyakova N.L. ^{[1
]}

Petyunin G.P. ^{[1
]}

Tugaibei I.A. ^{[1
]}

Rybakov V.B. ^{[2
]}

Chernyshev V.V. ^{[2
]}

Turov A.V. ^{[3
]}

机构：

[1] National University of Pharmacy

[2] M. V. Lomonosov Moscow State University

[3] Taras Shevchenko National University

来源：

Chemistry of Heterocyclic Compounds | 2007年 / 43卷 / 6期

关键词：

2-aminopyridines; 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids; Esters; Heterocyclic tricarbonylmethane derivatives; X-ray analysis;

D O I：

10.1007/s10593-007-0119-5

中图分类号：

学科分类号：

摘要：

An improved method for the preparation and purification of ethyl 2-hydroxy-4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carboxylates is proposed. According to 1H and 13C NMR spectroscopic data the synthesized compounds exist in DMSO solution in the 2-hydroxy-4-oxo form while in the crystal (at least for the case of the unsubstituted derivative) X-ray analysis shows that it occurs in the bipolar 2,4-dioxo form. © 2007 Springer Science+Business Media, Inc.

引用

页码：729 / 739

页数：10

共 50 条

[1] 4-hydroxy-2-quinolones. 120. Synthesis and structure of ethyl 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylates
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Petyunin, G. P.
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[3] 4-hydroxy-2-quinolones 143.: Synthesis, structure, and spectroscopic characteristics of ethyl 2-hydroxy-4-oxo-4H-pyrazino[1,2-a]pyrimidine-3-carboxylate
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[6] 4-hydroxy-2-quinolones -: 139.: Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids
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[8] 4-Hydroxy-2-quinolones 144. Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid and their diuretic properties
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[9] 4-HYDROXY-2-QUINOLONES 144. ALKYL-, ARYLALKYL-, AND ARYLAMIDES OF 2-HYDROXY-4-OXO-4H-PYRIDO[1,2-a]PYRIMIDINE-3-CARBOXYLIC ACID AND THEIR DIURETIC PROPERTIES
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