Influence of influenza vaccination on recurrent hospitalization in patients with heart failure; [Einfluss der Grippeimpfung auf wiederkehrende Hospitalisierungen von Herzinsuffizienzpatienten]

被引：0

作者：

Kaya H. ^{[1
]}

Beton O. ^{[1
]}

Acar G. ^{[2
]}

Temizhan A. ^{[3
]}

Cavusoğlu Y. ^{[4
]}

Guray U. ^{[5
]}

Zoghi M. ^{[6
]}

Ural D. ^{[7
]}

Ekmekci A. ^{[8
]}

Gungor H. ^{[9
]}

Sari I. ^{[10
]}

Oguz D. ^{[11
]}

Yucel H. ^{[1
]}

Zorlu A. ^{[1
]}

Yilmaz M.B. ^{[1
]}

机构：

[1] Faculty of Medicine, Department of Cardiology, Cumhuriyet University, Sivas

[2] Faculty of Medicine, Department of Cardiology, Sutcu Imam University, Kahramanmaras

[3] Cardiology Clinics, Yukses Ihtisas Training and Research Hospital, Ankara

[4] Faculty of Medicine, Department of Cardiology, Osmangazi University, Eskisehir

[5] Cardiology Clinics, Ankara Numune Training and Research Hospital, Ankara

[6] Faculty of Medicine, Department of Cardiology, Ege University, Izmir

[7] Faculty of Medicine, Department of Cardiology, Koc University, Istanbul

[8] Cardiology Clinics, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul

[9] Faculty of Medicine, Department of Cardiology, Adnan Menderes University, Aydın

[10] Faculty of Medicine, Department of Cardiology, Marmara University, Istanbul

[11] Faculty of Medicine, Department of Cardiology, Baskent University, Ankara

来源：

Herz | 2017年 / 42卷 / 3期

关键词：

Heart failure; Hospitalization; Influenza; Outpatients; Vaccination;

D O I：

10.1007/s00059-016-4460-2

中图分类号：

学科分类号：

摘要：

Background: The current study aimed to evaluate the influence of regular annual influenza vaccinations on cardiovascular (CV) death and heart failure-related hospitalizations (HFrH) in stable outpatients with heart failure with reduced ejection fraction. Methods: The Turkish research team-HF (TREAT-HF) is a network undertaking multicenter, observational cohort studies in HF. This study is a subgroup analysis of TREAT-HF outpatient cohorts who completed a questionnaire on influenza vaccination status and for whom follow-up data were available. A total of 656 patients with available follow-up data for CV death and HFrH including recurrent hospitalization were included in the study. Patients were classified into two groups: those who received regular influenza vaccination (40 %) and those who did not receive vaccination. Results: During a mean follow-up of 15 ±6 months, 113 (18 %) patients had CV death and 471 (72 %) patients had at least one HFrH. The CV death rate was similar in both groups of patients (16 vs. 19 %, p = 0.37), whereas, HFrH and recurrent HFrH were significantly less frequently encountered in patients who received regular influenza vaccination than in those who did not receive vaccination (43 vs. 92 % and 16 vs. 66 %, p < 0.001, respectively). In a multivariate Cox proportional hazards model – in addition to a few clinical factors – vaccination status (HR = 0.30, 95 % CI = 0.17–0.51, p < 0.001) and graduation from university (HR = 0.35, 95 % CI = 0.17–0.72, p = 0.004) remained independently associated with the risk of recurrent HFrH. Conclusion: Regular influenza vaccination does not influence CV deaths; however, it decreases HFrH including recurrent episodes of HFrH in outpatients with heart failure with reduced ejection fraction. © 2016, Springer Medizin Verlag.

引用

页码：307 / 315

页数：8

共 20 条

[1]

Fiore A.E., Uyeki T.M., Broder K., Finelli L., Euler G.L., Singleton J.A., Iskander J.K., Wortley P.M., Shay D.K., Bresee J.S., Cox N.J., Prevention andcontrol of influenza with vaccinations: recommendations of the Advisory Committeeon Immunization Practices (ACIP), MMWR Recomm Rep, 59, pp. 1-62, (2010)

[2]

Riddiough M.A., Sisk J.E., Bell J.C., Influenza vaccination: cost-effectiveness and public policy, JAMA, 249, pp. 3189-3195, (1983)

[3]

Davis M.M., Taubert K., Benin A.L., Brown D.W., Mensah G.A., Baddour L.M., Dunbar S., Krumholz H.M., Influenza vaccination as secondary prevention for cardiovascular disease: a science advisory from the American Heart Association/American College of Cardiology, J Am Coll Cardiol, 48, pp. 1498-1502, (2006)

[4]

McMurray J.J., Adamopoulos S., Anker S.D., Auricchio A., Bohm M., Dickstein K., Falk V., Filippatos G., Fonseca C., Gomez-Sanchez M.A., Jaarsma T., Kober L., Lip G.Y., Maggioni A.P., Parkhomenko A., Pieske B.M., Popescu B.A., Ronnevik P.K., Rutten F.H., Schwitter J., Seferovic P., Stepinska J., Trindade P.T., Voors A.A., Zannad F., Zeiher A., ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chroni

[5]

Naghavi M., Barlas Z., Siadaty S., Naguib S., Madjid M., Casscells W., Association of influenza vaccination and reduced risk of recurrent myocardial infarction, Circulation, 102, pp. 3039-3045, (2000)

[6]

Jackson L.A., Yu O., Heckbert S.R., Psaty B.M., Malais D., Barlow W.E., Thompson W.W., Influenza vaccination is not associated with a reduction in the risk of recurrent coronary events, Am J Epidemiol, 156, pp. 634-640, (2002)

[7]

Gurfinkel E.P., de la Fuente L.R., Mendiz O., Mautner B., Flu vaccination in acute coronary syndromes and planned percutaneous coronary interventions (FLUVACS) Study, Eur Heart J, 25, pp. 25-31, (2004)

[8]

Kopel E., Klempfner R., Goldenberg IInfluenza vaccination and survival in acute heart failure, Eur. J. Heart Fail., 16, pp. 264-270, (2014)

[9]

Vardeny O., Claggett B., Udell J.A., Packer M., Zile M., Rouleau J., Swedberg K., Desai A.S., Lefkowitz M., Shi V., McMurray J.J., Solomon S.D., Influenza Vaccination in Patients With Chronic Heart Failure: The PARADIGM-HF Trial, JACC Heart Fail, 4, 2, pp. 152-158, (2015)

[10]

Davis J.W., Lee E., Taira D.A., Chung R.S., Influenza vaccination, hospitalizations, and costs among members of a medicare managed care plan, Med Care, 39, 12, pp. 1273-1280, (2001)

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