Isoquercetin regulates SREBP-1C via AMPK pathway in skeletal muscle to exert antihyperlipidemic and anti-inflammatory effects in STZ induced diabetic rats

[1] Leon BM(2015)Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research World J Diabetes 6 1246-1258

[2] Maddox TM(2016)Targeting hepatic glucose output in the treatment of type 2 diabetes Nat Rev Drug Discov 15 786-804

[3] Rines AK(2004)Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions J Clin Invest 114 659-668

[4] Sharabi K(2011)Inflammatory markers in hyperlipidemia: from experimental models to clinical practice Curr Pharm Des 17 4132-4146

[5] Tavares CDJ(2013)AMPK, insulin resistance, and the metabolic syndrome J Clin Invest 123 2764-2772

[6] Puigserver P(2011)AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice Cell Metab 13 376-388

[7] Renard CB(2016)Flavonoids: an overview J Nutr Sci 5 e47-69

[8] Kramer F(2019)Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats Chem Biol Interact 303 62-721

[9] Johansson F(2003)Inhibitory effect of quercetin on carrageenan-induced inflammation in rats Life Sci 74 709-120

[10] Lamharzi N(2018)Isoquercetin ameliorates hyperglycemia and regulates key enzymes of glucose metabolism via insulin signaling pathway in streptozotocin-induced diabetic rats Eur J Pharmacol 829 112-230

[1] Leon BM(2015)Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research World J Diabetes 6 1246-1258

[2] Maddox TM(2016)Targeting hepatic glucose output in the treatment of type 2 diabetes Nat Rev Drug Discov 15 786-804

[3] Rines AK(2004)Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions J Clin Invest 114 659-668

[4] Sharabi K(2011)Inflammatory markers in hyperlipidemia: from experimental models to clinical practice Curr Pharm Des 17 4132-4146

[5] Tavares CDJ(2013)AMPK, insulin resistance, and the metabolic syndrome J Clin Invest 123 2764-2772

[6] Puigserver P(2011)AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice Cell Metab 13 376-388

[7] Renard CB(2016)Flavonoids: an overview J Nutr Sci 5 e47-69

[8] Kramer F(2019)Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats Chem Biol Interact 303 62-721

[9] Johansson F(2003)Inhibitory effect of quercetin on carrageenan-induced inflammation in rats Life Sci 74 709-120

[10] Lamharzi N(2018)Isoquercetin ameliorates hyperglycemia and regulates key enzymes of glucose metabolism via insulin signaling pathway in streptozotocin-induced diabetic rats Eur J Pharmacol 829 112-230