Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells

被引：0
作者：
X Gu
J Niu
D J Dorahy
R Scott
M V Agrez
机构：
[1] Newcastle Bowel Cancer Research Collaborative,
[2] Hunter Medical Research Institute,undefined
[3] John Hunter Hospital and The University of Newcastle,undefined
来源：
British Journal of Cancer | 2002年 / 87卷
关键词：
colon cancer; integrin αvβ6; matrix metalloproteinase; MAP kinase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
There is general consensus that matrix metalloproteinases are involved in tumour progression. We show herein that inhibition of integrin αvβ6 expression in colon cancer cells suppresses MMP-9 secretion. This integrin-mediated event is dependent upon direct binding between the β6 integrin subunit and extracellular signal-regulated kinase 2. Targetting either β6 or its interaction with extracellular signal-regulated kinase in order to inhibit matrix metalloproteinase activity may offer a useful therapeutic approach in preventing growth and spread of colon cancer.
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页码：348 / 351
页数：3
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