Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells

被引：0
作者：
X Gu
J Niu
D J Dorahy
R Scott
M V Agrez
机构：
[1] Newcastle Bowel Cancer Research Collaborative,
[2] Hunter Medical Research Institute,undefined
[3] John Hunter Hospital and The University of Newcastle,undefined
来源：
British Journal of Cancer | 2002年 / 87卷
关键词：
colon cancer; integrin αvβ6; matrix metalloproteinase; MAP kinase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
There is general consensus that matrix metalloproteinases are involved in tumour progression. We show herein that inhibition of integrin αvβ6 expression in colon cancer cells suppresses MMP-9 secretion. This integrin-mediated event is dependent upon direct binding between the β6 integrin subunit and extracellular signal-regulated kinase 2. Targetting either β6 or its interaction with extracellular signal-regulated kinase in order to inhibit matrix metalloproteinase activity may offer a useful therapeutic approach in preventing growth and spread of colon cancer.
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页码：348 / 351
页数：3
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共 163 条
[1]  
Agrez MV(1996)Multiplicity of fibronectin-binding alpha v integrin receptors in colorectal cancer Br J Cancer 73 887-892
[2]  
Bates RC(1994)The αvβ6 integrin promotes proliferation of colon carcinoma cells through a unique region of the β6 cytoplasmic domain J Cell Biol 127 547-556
[3]  
Mitchell D(1999)The αvβ6 integrin induces gelatinase B secretion in colon cancer cells Int J Cancer 81 90-97
[4]  
Wilson N(2002)Direct ERK-integrin binding: implications for tumour growth Oncogene 21 1370-1380
[5]  
Ferguson N(2000)Significance of α9β1 and αvβ6 integrin expression in breast carcinoma Breast Cancer 7 19-26
[6]  
Anseline P(1995)Expression of the β6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling J Cell Sci 108 2241-2251
[7]  
Sheppard D(1994)Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts Cell Adhes Comm 2 101-113
[8]  
Agrez MV(1996)Stimulation of 92-kDa gelatinase B promoter activity by Ras is mitogen activated protein kinase kinase 1 independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences J Biol Chem 271 10672-10680
[9]  
Chen A(1997)Regulation of 92 kDa type IV collagenase expression of the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signalling cascades Oncogene 14 1481-1493
[10]  
Cone RI(1991)Distribution of collagenase and tissue inhibitor of metalloproteinases (TIMP) in colorectal tumours Int J Cancer 49 666-672
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