Defective E-cadherin/catenin complexes in human cancer

被引：0
作者：
Van Aken E. [1 ]
De Wever O. [2 ]
Da Rocha C.A. [3 ]
Mareel M. [2 ]
机构：
[1] Department of Ophthalmology, Ghent University Hospital, 9000 Gent
[2] Laboratory of Experimental Cancerology, Ghent University Hospital, 9000 Gent
[3] Institute of Molecular Pathology and Immunology, University of Porto, 4200 Porto, Rua Roberto Frias s/n
来源：
Virchows Archiv | 2001年 / 439卷 / 6期
关键词：
Cadherin; Cancer; Catenin; Eye; Thyroid;
D O I：
10.1007/s004280100516
中图分类号：
学科分类号：
摘要：
Cancer is caused by a series of genomic changes leading directly or indirectly to disturbance of growth, differentiation and tissue integrity. Genomic, transcriptional or posttranscriptional alterations of E-cadherin/catenin complexes that are implicated in various steps of cancer development comprise mutational inactivation, transcriptional downregulation of E-cadherin sometimes accompanied by upregulation of N-cadherin, proteolysis of E-cadherin and posttranslational stabilisation of β-catenin and plakoglobin. The E-cadherin/catenin complex serves not only cell-cell adhesion but also transduces signals to the nucleus and to the cytoskeleton, either directly or through its connections with multiple other complexes. We review here the expression of E-cadherin/catenin in human cancers, emphasising methods of observation and prognostic interpretation of results. This is illustrated in thyroid lesions from the benign follicular adenoma to the extremely malignant anaplastic carcinoma. The eye is an organ largely neglected by students of cadherins and catenins. The implication of a variety of members of these molecular families in the embryonic development of the eye strongly suggests that disturbances of cadherin/catenin complexes are crucial also in the development of ocular tumours.
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页码：725 / 751
页数：26
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共 153 条
  • [71] Davidson M.K., Russ P.K., Glick G.G., Hoffman L.H., Chang M.S., Haselton F.R., Reduced expression of the adherens junction protein cadherin-5 in a diabetic retina, Am J Ophthalmol, 129, pp. 267-269, (2000)
  • [72] Davis A.A., Bernstein P.S., Bok D., Turner J., Nachtigal M., Hunt R.C., A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture, Invest Ophthalmol Vis Sci, 36, pp. 955-964, (1995)
  • [73] De Castro J., Gamallo C., Palacios J., Moreno-Bueno G., Rodriguez N., Feliu J., Gonzalez-Baron M., β-catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome, Virchows Arch, 437, pp. 599-604, (2000)
  • [74] De La Coste A., Romagnolo B., Billuart P., Renard C.-A., Buendia M.-A., Soubrane O., Fabre M., Chelly J., Beldjord C., Kahn A., Perret C., Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas, Proc Natl Acad Sci U S A, 95, pp. 8847-8851, (1998)
  • [75] Debruyne P., Vermeulen S., Mareel M., The role of the E-cadherin/catenin complex in gastrointestinal cancer, Acta Gastroenterol Belg, 62, pp. 393-403, (1999)
  • [76] DeLuca S.M., Gerhart J., Cochran E., Simak E., Blitz J., Mattiacci-Paessler M., Knudsen K., George-Weinstein M., Hepatocyte growth factor/scatter factor promotes a switch from E- to N-cadherin in chick embryo epiblast cells, Exp Cell Res, 251, pp. 3-15, (1999)
  • [77] Di Renzo M.F., Olivero M., Ferro S., Prat M., Bongarzone I., Pilotti S., Belfiore A., Costantino A., Vigneri R., Pierotti M.A., Et al., Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas, Oncogene, 7, pp. 2549-2553, (1992)
  • [78] Doherty P., Walsh F.S., The contrasting roles of N-CAM and N-cadherin as neurite outgrowth-promoting molecules, J Cell Sci Suppl, 15, pp. 13-21, (1991)
  • [79] Doherty P., Walsh F.S., CAM-FGF receptor interactions: A model for axonal growth, Mol Cell Neurosci, 8, pp. 99-111, (1996)
  • [80] Eads C.A., Lord R.V., Kurumboor S.K., Wickramasinghe K., Skinner M.L., Long T.I., Peters J.H., DeMeester T.R., Danenberg K.D., Danenberg P.V., Laird P.W., Skinner K.A., Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma, Cancer Res, 60, pp. 5021-5026, (2000)
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