Deep Brain Stimulation in Cluster Headache: Hypothalamus or Midbrain Tegmentum?

被引:0
作者
Manjit S. Matharu
Ludvic Zrinzo
机构
[1] Institute of Neurology,Headache Group
[2] Institute of Neurology and the National Hospital for Neurology and Neurosurgery,Unit of Functional Neurosurgery
来源
Current Pain and Headache Reports | 2010年 / 14卷
关键词
Cluster headache; Functional imaging; Neuromodulation; Deep brain stimulation;
D O I
暂无
中图分类号
学科分类号
摘要
Functional and structural neuroimaging studies have provided pivotal insights into the pathophysiology of trigeminal autonomic cephalalgias (TACs), particularly cluster headache (CH). Functional imaging studies using positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) in TACs have reported activation of the posterior hypothalamus. A structural neuroimaging study using voxel-based morphometry in CH reported increased volume of the hypothalamic gray, although another larger study failed to reproduce this finding. These studies in CH prompted the use of stereotactic stimulation of the target point identified by functional and structural neuroimaging. The precise anatomical localization of the deep brain stimulation (DBS) target places it at the midbrain tegmentum rather than the posterior hypothalamus. A comparison of the PET and fMRI studies in TACs reveals that the diencephalic/mesencephalic activation is more posteroinferior in the PET studies, straddling the hypothalamus and midbrain tegmentum, whereas the activation is centered on the hypothalamus in the higher spatial resolution fMRI studies. To optimize the outcomes from DBS, it is likely that patients will need to be studied individually using functional imaging techniques that have high spatial and temporal resolution to enable targeting of the appropriate locus with stereotactic stimulation.
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页码:151 / 159
页数:8
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