Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-fat diet/streptozotocin-induced diabetic rats

被引:0
作者
Qingmiao Shao
Lei Meng
Sharen Lee
Gary Tse
Mengqi Gong
Zhiwei Zhang
Jichao Zhao
Yungang Zhao
Guangping Li
Tong Liu
机构
[1] Second Hospital of Tianjin Medical University,Tianjin Key Laboratory of Ionic
[2] Li Ka Shing Institute of Health Sciences,Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology
[3] The University of Auckland,Laboratory of Cardiovascular Physiology
[4] Tianjin University of Sport,Auckland Bioengineering Institute
来源
Cardiovascular Diabetology | / 18卷
关键词
Atrial fibrillation; Empagliflozin; SGLT-2 inhibitor; Atrial remodeling; Mitochondrial function; Diabetic rats;
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[11]  
Chalmers J(2017)The sodium–glucose co-transporter 2 inhibitor, empagliflozin, protects against diabetic cardiomyopathy by inhibition of the endoplasmic reticulum stress pathway Cell Physiol Biochem 41 2503-2512
[12]  
Pillai A(1995)Mitochondrial membrane potential monitored by JC-1 dye Methods Enzymol 260 406-417
[13]  
Aksnes TA(2017)Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes Cardiovasc Diabetol 16 120-373
[14]  
Schmieder RE(2015)Atrial fibrillation in patients with diabetes: molecular mechanisms and therapeutic perspectives Cardiovasc Diagn Ther 5 364-222
[15]  
Kjeldsen SE(2015)Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-alpha/NF-kappaB/TGF-beta signal transduction pathway in alloxan-induced diabetic rabbits J Cardiovasc Electrophysiol 26 211-819
[16]  
Ghani S(2016)NADPH oxidase inhibitor apocynin prevents atrial remodeling in alloxan-induced diabetic rabbits Int J Cardiol 221 812-564
[17]  
Hua TA(2008)The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model Exp Diabetes Res 2008 9-1898
[18]  
Julius S(2014)Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients Circulation 130 554-246
[19]  
Zinman B(2009)Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart J Am Coll Cardiol 54 1891-306
[20]  
Wanner C(2017)Empagliflozin improves left ventricular diastolic dysfunction in a genetic model of type 2 diabetes Cardiovasc Drugs Ther 31 233-210