Plasma IGF-1 and IGFBP-3 may be imprecise surrogates for breast concentrations: an analysis of healthy women

被引:0
作者
Adana A. Llanos
Theodore M. Brasky
Ramona G. Dumitrescu
Catalin Marian
Kepher H. Makambi
Bhaskar V. S. Kallakury
Scott L. Spear
David J. Perry
Rafael J. Convit
Mary E. Platek
Lucile L. Adams-Campbell
Jo L. Freudenheim
Peter G. Shields
机构
[1] The Ohio State University Comprehensive Cancer Center,Division of Population Sciences
[2] Georgetown University Medical Center,Lombardi Comprehensive Cancer Center
[3] Saba University School of Medicine,Steinhardt School of Culture, Education and Human Development
[4] University of Medicine and Pharmacy Timisoara,Department of Social and Preventive Medicine
[5] MedStar Georgetown University Hospital,undefined
[6] MedStar Washington Hospital Center,undefined
[7] New York University,undefined
[8] University at Buffalo,undefined
[9] State University of New York,undefined
来源
Breast Cancer Research and Treatment | 2013年 / 138卷
关键词
IGF-1; IGFBP-3; IGF-1/IGFBP-3; Breast tissues; Plasma; Race; Oral contraceptive use;
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中图分类号
学科分类号
摘要
We investigated insulin-like growth factor (IGF)-1 and IGF binding protein (IGFBP)-3 concentrations in histologically normal breast tissues and assessed their association with plasma concentrations, and breast cancer risk factors. IGF-1 and IGFBP-3 were assessed in plasma and breast tissues of 90 women with no history of any cancer and undergoing reduction mammoplasty. Pearson correlations and ANOVAs were used to describe plasma-breast associations and biomarker differences by breast cancer risk factors, respectively. Multivariable regression models were used to determine associations between risk factors, and breast IGF-1 and IGFBP-3. The mean age of the study sample was 37.3 years, 58 % were white, and generally these women were obese (mean BMI = 30.8 kg/m2). We observed no plasma-breast correlation for IGF-1, IGFBP-3, or IGF-1/IGFBP-3 (r = −0.08, r = 0.14, and r = 0.03, respectively; p-values >0.05). Through age- and BMI-adjusted analysis, BMI and years of oral contraceptive (OC) use were inversely associated with breast IGF-1 (p-values = 0.02 and 0.003, respectively) and age was associated with breast IGFBP-3 (p = 0.01), while breast IGF-1/IGFBP-3 was higher in blacks than whites (1.08 vs. 0.68, p = 0.04) and associated with age and BMI (p-values = 0.03 and 0.002, respectively). In multivariable-adjusted models, some breast cancer risk factors studied herein explained 24, 10, and 15 % of the variation in breast IGF-1, IGFBP-3, and IGF-1/IGFBP-3, respectively. While reasons for the lack of plasma-breast hormone correlations in these cancer-free women are unknown, several factors were shown to be associated with breast concentrations. The lack of correlation between blood and tissue IGF-1 and IGFBP-3 suggests that studies of breast cancer risk assessing blood IGF-1 and IGFBP-3 may have important limitations in understanding their role in breast carcinogenesis.
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页码:571 / 579
页数:8
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