Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response

[11] Rockette-Wagner B(1998)Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects Mol Genet Metab 65 181-31

[12] Edelstein SL(2014)Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation PLoS One 9 e91675-10G

[13] Pearson ER(2016)The relationship between branched-chain amino acid related metabolomic signature and insulin resistance: a systematic review J Diabetes Res 2016 2794591-412

[14] DeFronzo RA(2020)Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism Am J Physiol Cell Physiol 318 C615-1743

[15] Ferrannini E(2021)Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases J Diabetes Investig 12 21-4855

[16] Sato Y(2002)Insulin resistance as the core defect in type 2 diabetes mellitus Am J Cardiol 90 3G-1231

[17] Felig P(2000)Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study BMJ 321 405-139

[18] Wahren J(2000)Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia Am J Hum Genet 66 1736-undefined

[19] Garneau L(2022)Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1 J Biol Chem 298 102379-undefined

[20] Aguer C(2017)Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice J Physiol 595 4845-undefined

[11] Rockette-Wagner B(1998)Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects Mol Genet Metab 65 181-31

[12] Edelstein SL(2014)Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation PLoS One 9 e91675-10G

[13] Pearson ER(2016)The relationship between branched-chain amino acid related metabolomic signature and insulin resistance: a systematic review J Diabetes Res 2016 2794591-412

[14] DeFronzo RA(2020)Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism Am J Physiol Cell Physiol 318 C615-1743

[15] Ferrannini E(2021)Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases J Diabetes Investig 12 21-4855

[16] Sato Y(2002)Insulin resistance as the core defect in type 2 diabetes mellitus Am J Cardiol 90 3G-1231

[17] Felig P(2000)Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study BMJ 321 405-139

[18] Wahren J(2000)Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia Am J Hum Genet 66 1736-undefined

[19] Garneau L(2022)Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1 J Biol Chem 298 102379-undefined

[20] Aguer C(2017)Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice J Physiol 595 4845-undefined