Epidermal stem cells in wound healing and their clinical applications

被引：0
作者：
Ronghua Yang
Fengxia Liu
Jingru Wang
Xiaodong Chen
Julin Xie
Kun Xiong
机构：
[1] The First People’s Hospital of Foshan,Department of Burn Surgery
[2] Xinjiang Medical University,Department of Human Anatomy, School of Basic Medical Science
[3] First Affiliated Hospital of Sun Yat-Sen University,Department of Burn Surgery
[4] Central South University,Department of Anatomy and Neurobiology, School of Basic Medical Science, Morphological Sciences Building
来源：
Stem Cell Research & Therapy | / 10卷
关键词：
Epidermal stem cells; Wound healing; Signaling pathway; Epithelial regeneration;
D O I：
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中图分类号：
学科分类号：
摘要：
The skin has important barrier, sensory, and immune functions, contributing to the health and integrity of the organism. Extensive skin injuries that threaten the entire organism require immediate and effective treatment. Wound healing is a natural response, but in severe conditions, such as burns and diabetes, this process is insufficient to achieve effective treatment. Epidermal stem cells (EPSCs) are a multipotent cell type and are committed to the formation and differentiation of the functional epidermis. As the contributions of EPSCs in wound healing and tissue regeneration have been increasingly attracting the attention of researchers, a rising number of therapies based on EPSCs are currently under development. In this paper, we review the characteristics of EPSCs and the mechanisms underlying their functions during wound healing. Applications of EPSCs are also discussed to determine the potential and feasibility of using EPSCs clinically in wound healing.
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