A Comparative Evaluation of Amlodipine and Hydrochlorothiazide as Monotherapy in the Treatment of Isolated Systolic Hypertension in the Elderly

被引:0
作者
C. Calvo
F. Gude
J. Abellán
J. Oliván
M. Olmos
L. Pita
D. Sánz
J. Sarasa
J. Bueno
J. Herrera
J. Macías
T. Sagastagoitia
B. Ferro
A. Vega
J. Martínez
机构
[1] Hospital Clínico Universitario,Hypertension Unit and Epidemiology Department
[2] C/ Choupana,Hypertension Unit
[3] s/n,Department of Nephrology
[4] Murcia S. Andrés Primary Care Center,Department of Internal Medicine
[5] Hospital Virgen Macarena,Department of Clinical Nephrology
[6] Hospital Universitario La Fe,Department of Preventive Medicine
[7] Hospital Universitario Santa Cristina,Department of Internal Medicine
[8] Clínica Puerta de Hierro,Department of Nephrology
[9] Hospital Miguel Servet,Department of Nephrology
[10] Hospital Clínico Universitario,Department of Cardiology
[11] Hospital Central de Asturias,Medical Division
[12] Hospital Clinico,undefined
[13] Hospital Civil de Basurto,undefined
[14] Pfizer,undefined
[15] S.A.,undefined
来源
Clinical Drug Investigation | 2000年 / 19卷
关键词
Systolic Blood Pressure; High Blood Pressure; Calcium Antagonist; Amlodipine; Hydrochlorothiazide;
D O I
暂无
中图分类号
学科分类号
摘要
Objective: The purpose of this 8-week, randomised, single-blind, parallel group, multicentre, comparative study was to evaluate the efficacy, safety and tolerability of the dihydropyridine calcium antagonist amlodipine versus the thiazide diuretic hydrochlorothiazide for control of isolated systolic hypertension (ISH) in elderly patients aged 60 years or more.
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页码:317 / 326
页数:9
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共 51 条
[1]  
Wilking S.V.(1991)Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP) JAMA 265 3255-64
[2]  
Belanger A.(1988)Determinants of isolated systolic hypertension JAMA 260 3451-5
[3]  
Kannel W.B.(1990)Isolated systolic hypertension in the elderly J Hypertens 8 393-405
[4]  
Staessen J.(1998)The clinical significance of systolic hypertension Am J Hypertens 11 182-5S
[5]  
Amery A.(1998)Epidemiología de las enfermedades cardiovasculares en la población anciana española Rev Esp Cardiol 51 864-73
[6]  
Fagard R.(1990)Mortality after 10 1/2 years for hypertensive participants in the Multiple Risk Factor Intervention Trial Circulation 82 1616-28
[7]  
Cushman W.C.(1993)Blood pressure, systolic and diastolic, and cardiovascular risks: US population data Arch Intern Med 153 598-615
[8]  
Sáez T.(1997)Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators Lancet 350 757-64
[9]  
Suárez C.(1990)Blood pressure, stroke, and coronary heart disease: part 2. Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context Lancet 335 827-38
[10]  
Blanco F.(1993)The fifth report of the Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure (JNC V) Arch Intern Med 153 154-83