Brain white matter tract integrity as a neural foundation for general intelligence

被引：0
作者：
L Penke
S Muñoz Maniega
M E Bastin
M C Valdés Hernández
C Murray
N A Royle
J M Starr
J M Wardlaw
I J Deary
机构：
[1] Centre for Cognitive Ageing and Cognitive Epidemiology,Department of Psychology
[2] The University of Edinburgh,Department of Clinical Neurosciences
[3] The University of Edinburgh,Department of Clinical Neurosciences
[4] Scottish Imaging Network,Division of Health Sciences (Medial Physics)
[5] A Platform for Scientific Excellence (SINAPSE) Collaboration,undefined
[6] The University of Edinburgh,undefined
[7] Brain Research Imaging Centre,undefined
[8] The University of Edinburgh,undefined
[9] The University of Edinburgh,undefined
[10] Geriatric Medicine Unit,undefined
[11] The University of Edinburgh,undefined
[12] Royal Victoria Hospital,undefined
来源：
Molecular Psychiatry | 2012年 / 17卷
关键词：
diffusion tensor imaging; information-processing speed; intelligence; magnetisation transfer imaging; tractography; white matter;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
General intelligence is a robust predictor of important life outcomes, including educational and occupational attainment, successfully managing everyday life situations, good health and longevity. Some neuronal correlates of intelligence have been discovered, mainly indicating that larger cortices in widespread parieto-frontal brain networks and efficient neuronal information processing support higher intelligence. However, there is a lack of established associations between general intelligence and any basic structural brain parameters that have a clear functional meaning. Here, we provide evidence that lower brain-wide white matter tract integrity exerts a substantial negative effect on general intelligence through reduced information-processing speed. Structural brain magnetic resonance imaging scans were acquired from 420 older adults in their early 70s. Using quantitative tractography, we measured fractional anisotropy and two white matter integrity biomarkers that are novel to the study of intelligence: longitudinal relaxation time (T1) and magnetisation transfer ratio. Substantial correlations among 12 major white matter tracts studied allowed the extraction of three general factors of biomarker-specific brain-wide white matter tract integrity. Each was independently associated with general intelligence, together explaining 10% of the variance, and their effect was completely mediated by information-processing speed. Unlike most previously established neurostructural correlates of intelligence, these findings suggest a functionally plausible model of intelligence, where structurally intact axonal fibres across the brain provide the neuroanatomical infrastructure for fast information processing within widespread brain networks, supporting general intelligence.
引用
收藏
页码：1026 / 1030
页数：4
相关论文
共 148 条
  • [21] Tranel D(2011)The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond Int J Stroke 6 547-198
  • [22] Damasio H(1975)Brain ageing, cognition in youth and old age, and vascular disease in the Lothian Birth Cohort 1936: rationale, design and methodology of the imaging protocol J Psychiatr Res 12 189-310
  • [23] Barbey AK(2007)Mini-mental state: a practical method for grading the cognitive state of patients for the clinician Magn Reson Imaging 25 303-10
  • [24] Colom R(2010)Quantitative assessment of intracranial tumor response to dexamethasone using diffusion, perfusion and permeability magnetic resonance imaging NeuroImage 51 1-267
  • [25] Solomon J(1994)Quantifying the effects of normal ageing on white matter structure using unsupervised tract shape modelling Biophys J 66 259-155
  • [26] Krueger F(2007)MR diffusion tensor spectroscopy and imaging NeuroImage 34 144-385
  • [27] Forbes C(2009)Probabilistic diffusion tractography with multiple fibre orientations: what can we gain? NeuroImage 45 377-1561
  • [28] Grafman J(2007)Reproducibility of tract segmentation between sessions using an unsupervised modelling-based approach IEEE Trans Med Imaging 26 1555-347
  • [29] Salthouse TA(2008)A probabilistic model-based approach to consistent white matter tract segmentation NeuroImage 39 336-157
  • [30] Bressler SL(2009)Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification Med Image Comput Comput Assist Interv 12 150-399
12345678910