Flow-induced mechanotransduction in skeletal cells

被引：37

作者：

Alfieri R. ^{[1
]}

Vassalli M. ^{[2
]}

Viti F. ^{[2
]}

机构：

[1] Institute of Molecular Genetics “Luigi Luca Cavalli-Sforza” - National Research Council (IGM-CNR), Via Abbiategrasso, 207, Pavia

[2] Institute of Biophysics - National Research Council (IBF-CNR), Via De Marini, 6, Genoa

来源：

Biophysical Reviews | 2019年 / 11卷 / 5期

关键词：

Bone cells; Fluid shear stress; Mechanotransduction;

D O I：

10.1007/s12551-019-00596-1

中图分类号：

学科分类号：

摘要：

Human body is subject to many and variegated mechanical stimuli, actuated in different ranges of force, frequency, and duration. The process through which cells “feel” forces and convert them into biochemical cascades is called mechanotransduction. In this review, the effects of fluid shear stress on bone cells will be presented. After an introduction to present the major players in bone system, we describe the mechanoreceptors in bone tissue that can feel and process fluid flow. In the second part of the review, we present an overview of the biological processes and biochemical cascades initiated by fluid shear stress in bone cells. © 2019, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature.

引用

页码：729 / 743

页数：14

共 160 条

[1]

Abed E., Labelle D., Martineau C., Loghin A., Moreau R., Expression of transient receptor potential (TRP) channels in human and murine osteoblast-like cells, Mol Membr Biol, 26, pp. 146-158, (2009)

[2]

Alford A.I., Jacobs C.R., Donahue H.J., Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism small star, filled, Bone., 33, pp. 64-70, (2003)

[3]

Arita N.A., Pelaez D., Cheung H.S., Activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) is needed for the TGFbeta-induced chondrogenic and osteogenic differentiation of mesenchymal stem cells, Biochem Bioph Res Co, 405, pp. 564-569, (2011)

[4]

Arnsdorf E.J., Tummala P., Jacobs C.R., Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate, PLoS One, 4, 4, (2009)

[5]

Arnsdorf E.J., Tummala P., Kwon R.Y., Jacobs C.R., Mechanically induced osteogenic differentiation - the role of RhoA, ROCKII and cytoskeletal dynamics, J Cell Sci, 122, pp. 546-553, (2009)

[6]

Arthur A., Zannettino A., Panagopoulos R., Kobla S., Sims N.A., Stylianou C., Matsuo K., Gronthos S., EphB/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation, Bone., 48, pp. 533-542, (2011)

[7]

Awane M., Andres P.G., Li D.J., Reinecker H.C., NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 betainduced chemokine promoter activation in intestinal epithelial cells, J Immunol, 162, 9, pp. 5337-5344, (1999)

[8]

Bennett B.C., Purdy M.D., Baker K.A., Acharya C., McIntire W.E., Stevens R.C., Zhang Q., Harris A.L., Abagyan R., Yeager M., An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels, Nat Commun, 7, (2016)

[9]

Berman H.M., Westbrook J., Feng Z., Gilliland G., Bhat T.N., Weissig H., Shindyalov I.N., Bourne P.E., The Protein Data Bank, NAR., 28, pp. 235-242, (2000)

[10]

Bidwell J.P., Pavalko F.M., The load-bearing mechanosome revisited, Clin Rev Bone Miner Metab, 8, pp. 213-223, (2010)

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