The influence of LIF (Leukemia Inhibitory Factor) on the functional status of R1 mouse embryonic stem cells

被引：0
|
作者：
Lobanok E.S. [1 ]
Mezhevikina L.M. [2 ]
Belyanovich L.M. [1 ]
Petrova R.R. [2 ]
Vasilevich I.B. [1 ]
Volotovsky I.D. [1 ]
Fesenko E.E. [2 ]
机构：
[1] Institute of Cell Biophysics and Cell Technology, NAN Belarus, Minsk 220072
[2] Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290
来源：
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry | 2009年 / 3卷 / 1期
关键词：
Cell cycle; Cytokine LIF; Embryonic stem cells; Proliferation;
D O I：
10.1134/S1990750809010077
中图分类号：
学科分类号：
摘要：
The influence of cytokine LIF (Leukemia Inhibitory Factor) on the viability, and proliferation of mouse embryonic stem cells (ESC) (R1 cell line) and their distribution by cell cycle stages has been investigated. LIF (5-20 ng/ml) increased growth of colonies and maintained high proliferative and pluripotent properties of R1 cells. LIF was also involved into the inhibition of spontaneous cell differentiation and apoptotic cell death; it also decreased the rations of S/G2 + M cell cycle and doubling-time of cell population. © Pleiades Publishing, Ltd. 2009.
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页码：54 / 57
页数：3
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