Genetic Approach to Diagnosis of Intellectual Disability

被引：0

作者：

Ratna Dua Puri

Moni Tuteja

I. C. Verma

机构：

[1] Sir Ganga Ram Hospital,Ganga Ram Institute of Postgraduate Medical Research and Education, Institute of Medical Genetics & Genomics

来源：

The Indian Journal of Pediatrics | 2016年 / 83卷

关键词：

Intellectual disability; Etiology; Microarray; Metabolic; Single gene disorders; Next generation sequencing;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Intellectual disability is a non-specific phenotype present in a genetically heterogeneous group of disorders. It is characterized by deficits in intellectual and adaptive functioning, presenting before 18 y of age. Identifying the cause of ID is important to provide treatment where available, genetic counseling, recurrence risks and reproductive options for subsequent pregnancies. Advances in technology, especially next generation sequencing and microarrays, have greatly increased the diagnostic yield of evaluation in cases of ID. This paper describes the points in history taking and examination in the evaluation of a proband, and discusses the proper use of newer diagnostic technologies.

引用

页码：1141 / 1149

页数：8

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