Circadian disturbances and frailty risk in older adults

被引：15
|
作者：
Cai, Ruixue [1 ,2 ]
Gao, Lei [1 ,3 ,4 ]
Gao, Chenlu [1 ,3 ,4 ]
Yu, Lei [5 ]
Zheng, Xi [1 ]
Bennett, David A. [5 ]
Buchman, Aron S. [5 ]
Hu, Kun [1 ,3 ,4 ]
Li, Peng [1 ,3 ,4 ]
机构：
[1] Brigham & Womens Hosp, Div Sleep & Circadian Disorders, Med Biodynam Program, Boston, MA 02115 USA
[2] Southeast Univ, Sch Publ Hlth, Nanjing 210000, Jiangsu, Peoples R China
[3] Harvard Med Sch, Div Sleep Med, Boston, MA 02115 USA
[4] Harvard Med Sch, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA
[5] Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Chicago, IL 60612 USA
来源：
NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期
关键词：
INCIDENT ALZHEIMERS-DISEASE; REST-ACTIVITY RHYTHMS; COGNITIVE DECLINE; PHYSICAL FRAILTY; BRAIN PATHOLOGY; ASSOCIATION; SLEEP; STRENGTH;
D O I：
10.1038/s41467-023-42727-z
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Frailty is characterized by diminished resilience to stressor events. It is associated with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates similar to 24-h rhythms in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. We investigated prospective associations of circadian disturbances with incident frailty in over 1000 older adults who had been followed annually for up to 16 years. We found that decreased rhythm strength, reduced stability, or increased variation were associated with a higher risk of incident frailty and faster progress of frailty over time. Perturbed circadian rest-activity rhythms may be an early sign or risk factor for frailty in older adults.
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页数：9
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