Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk

被引：0
作者：
Bedia Agachan Cakmakoglu
Rukset Attar
Ozlem Timirci Kahraman
Altay Burak Dalan
Ahmet Cem Iyibozkurt
Ates Karateke
Erkut Attar
机构：
[1] Istanbul University,Department of Molecular Medicine, Institute for Experimental Medicine Research
[2] Yeditepe University Hospital,Department of Obstetrics and Gynecology
[3] Istanbul University,Department of Obstetrics and Gynecology, Istanbul Medical School
[4] Zeynep Kamil Research and Training Hospital,undefined
来源：
Molecular Biology Reports | 2011年 / 38卷
关键词：
Cox-2; Epithelial ovarian carcinoma; Polymorphism;
D O I：
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学科分类号：
摘要：
In this study, we aimed to investigate a possible association of the COX-2 polymorphisms (−765G→C and −1195A→G) and with the risk of developing epithelial ovarian carcinoma (EOC). COX-2 gene polymorphisms was investigated in 111 healthy women and 57 patients with EOC. Individuals who had −765 CG, −1195 AA genotype, and −765 C allele had increased risk for ovarian carcinoma (P < 0.01) and individuals with −765 GG, −1195 AG genotypes and −1195 G allele seem to be protected from ovarian carcinoma (P < 0.01). Haplotype analysis confirmed the association of COX-2 gene variants with ovarian carcinoma and revealed that the frequencies of −765C: −1195A haplotype frequencies was significantly higher in patients as compared with those of controls (P = 0.048). We state that there appears to be a modulating role for the COX-2 −1195A→G and −765G→C polymorphisms in the development of EOC. To the best of our knowledge, this is the first study to show such an association.
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页码：3481 / 3486
页数：5
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